Evidence map›Paper›PMID 32424708›Full record

ArticleJournal of autism and developmental disorders2021

Functional Outcomes of Children Identified Early in the Developmental Period as at Risk for ASD Utilizing the The Norwegian Mother, Father and Child Cohort Study (MoBa).

Nina Stenberg, Synnve Schjølberg, Frederick Shic, Fred Volkmar, Anne-Siri Øyen, Michaeline Bresnahan, Britt Kveim Svendsen, Stephen von Tetzchner, Nina Torheim Thronæs, Suzanne Macari and 4 more

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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  8. What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT.Autism research : official journal of the International Society for Autism Research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nina Stenberg *Oslo University Hospital, Oslo, Norway.
Synnve Schjølberg *Norwegian Institute of Public Health, Oslo, Norway.
Frederick ShicCenter for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA.
Fred VolkmarSchool of Medicine, Child Study Center, Yale University, New Haven, USA.
Anne-Siri ØyenNorwegian Institute of Public Health, Oslo, Norway.
Michaeline BresnahanMailman School of Public Health, Columbia University, New York, USA.
Britt Kveim SvendsenOslo University Hospital, Oslo, Norway.
Stephen von TetzchnerDepartment of Psychology, UiO, Oslo, Norway.
Nina Torheim ThronæsDepartment of Education, UiT - The Arctic University of Norway, PB 6050, 9037, Tromsø, Norway.
Suzanne MacariSchool of Medicine, Child Study Center, Yale University, New Haven, USA.
Domenic V Cicchetti *School of Medicine, Child Study Center, Yale University, New Haven, USA.
Katarzyna ChawarskaSchool of Medicine, Child Study Center, Yale University, New Haven, USA.
Pål SurenNorwegian Institute of Public Health, Oslo, Norway.
Roald A ØienDepartment of Education, UiT - The Arctic University of Norway, PB 6050, 9037, Tromsø, Norway. roald.a.oien@uit.no.ORCID http://orcid.org/0000-0003-3698-2184

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Statistical Analysis CoreP50MH115716 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$11.5M
Mechanisms of Brain Dysmorphology in MN1 C-Terminal Truncation Syndrome, a Novel Intellectual Developmental Disability Disorder P50HD103524 · NICHD · UNIVERSITY OF WASHINGTON · PI DANIEL DOHERTY · 2020 to 2026
$9.9M
Attentional, temperamental, and physiological process underlying anxiety in preschoolers with ASDR01MH111652 · NIMH · YALE UNIVERSITY · PI CHAWARSKA, KATARZYNA · 2017 to 2021
$3.9M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS P50 HD103524NIMH NIH HHS P50 MH115716NIMH NIH HHS R01 MH111652
6 · The paper itself

Abstract

Early identification of autism spectrum disorder (ASD) is regarded as crucial for swift access to early intervention and, subsequently, better outcomes later in life. However, current instruments miss large proportions of children who later go on to be diagnosed with ASD, raising a question of what these instruments measure. The present study utilized data from the Norwegian Mother, Father, and Child Cohort Study and the Autism Birth Cohort study to explore the subsequent developmental and diagnostic characteristics of children raising developmental concern on the six-critical discriminative item criterion of the M-CHAT (DFA6) at 18 months of age (N = 834). The DFA6 identified 28.8% of children diagnosed with ASD (N = 163), but 4.4% with language disorder (N = 188) and 81.3% with intellectual disability (N = 32) without ASD. Scoring in the «at-risk» range was associated with lower IQ, impaired functional language, and greater severity of autism symptoms whether children had ASD or not.

Indexed as

Child DevelopmentAutism Spectrum DisorderChildChild, PreschoolCohort StudiesEarly DiagnosisFathersFemaleHumansInfantIntellectual DisabilityLanguage DisordersMaleMothersNorwayProspective StudiesADOSAutism spectrum disordersCognitionEarly identificationFather and child cohort studyLanguageMoBaNorwegian motherScreeningVineland

Identifiers

PMID32424708
PMCPMC7954713

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.