ArticleFish physiology and biochemistry2020
Antioxidative and immunoprotective potential of Chlorella vulgaris dietary supplementation against chlorpyrifos-induced toxicity in Nile tilapia.
Article in Fish physiology and biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- The protective role of Artemisia annua against chlorpyrifos toxicity in Nile tilapia.Scientific reports · 2026Article
- Dietary Spirulina Ameliorates Arsenic-Induced Toxicity in Nile Tilapia, Oreochromis niloticus.Veterinary medicine and science · 2026Article
- Heat shock proteins in farmed aquatic animals: advancing animal health and welfare management through building resilience.Frontiers in immunology · 2026Review
- Chemoprotection and Immunostimulation of Alpha-Lipoic Acid Against Chlorpyrifos-Induced Toxicosis in Nile Tilapia,Scientifica · 2025Article
- Immune protective, stress indicators, antioxidant, histopathological status, and heat shock protein gene expression impacts of dietary Bacillus spp. against heat shock in Nile tilapia, Oreochromis niloticus.BMC veterinary research · 2024Article
- Toxicity Evaluation, Oxidative, and Immune Responses of Mercury on Nile Tilapia: Modulatory Role of Dietary Nannochloropsis oculata.Biological trace element research · 2024Article
- Dietary microalgal-fabricated selenium nanoparticles improve Nile tilapia biochemical indices, immune-related gene expression, and intestinal immunity.BMC veterinary research · 2024Article
- Nutritional and immunological evaluation of Nannochloropsis oculata as a potential Nile tilapia-aquafeed supplement.BMC veterinary research · 2023Article
- Pesticide Pollution: Detrimental Outcomes and Possible Mechanisms of Fish Exposure to Common Organophosphates and Triazines.Journal of xenobiotics · 2022Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study highlighted the effects of chronic chlorpyrifos (CPF) exposure on Nile tilapia (Oreochromis niloticus) and the benefits of using dietary Chlorella vulgaris (Ch) to ameliorate CPF-induced toxicity. Genes encoding antioxidant enzymes and stress-responsive proteins in the liver as well as cytokine expression in the spleen and head kidney were evaluated in O. niloticus fed with a basal diet or diets containing 1, 2, and 3% of supplementary Ch against 15 mg/L CPF at 4 and 8 weeks. CPF-exposed groups displayed a notable induction in the hepatic expression of heat shock protein 70/hsp70, glutathione peroxidase/GPx, and glutathione synthase/GSS, while glutathione reductase/GSR was markedly decreased. The mRNA levels of interleukin 1β/IL-1β, TNF-α, transforming growth factor β1/TGFβ1, and interleukin 8/ IL-8 in the spleen and head kidney increased significantly after CPF exposure. Interestingly, Ch supplementation, particularly at levels 2 and 3%, was able to modulate the stress and immune-related genes of Nile tilapia sub-chronically exposed to CPF. These outcomes provide valuable insights regarding the toxic impact of chronic exposure to CPF in fish at the molecular level and a better understanding of the Ch dietary vital roles. Besides, our findings encourage adequate monitoring of pesticide levels owing to its impacts on fish health and human as a final consumer.
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