ArticleSurgical endoscopy2021
Marginal ulceration following Roux-en-Y gastric bypass: risk factors for ulcer development, recurrence and need for revisional surgery.
Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05799105 (OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers After Bariatric Surgery), which is not on this map. Cited by 42 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers After Bariatric Surgery
Who cites it
42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Effect of Helicobacter pylori infection on metabolic and bariatric surgical complications: a systematic review and meta-analysis.Updates in surgery · 2025Pooled it
- Demographic Factors Associated with Postoperative Complications in Primary Bariatric Surgery: A Rapid Review.Obesity surgery · 2025Pooled it
- Update on antithrombotic therapy and body mass: a clinical consensus statement of the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy and the European Society of Cardiology Working Group on Thrombosis.European heart journal. Cardiovascular pharmacotherapy · 2024Pooled it
- Smoking status predicts anastomotic leak after esophagectomy: a systematic review & meta-analysis.Surgical endoscopy · 2024Pooled it
- Predictors of marginal ulcer after gastric bypass: a systematic review and meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Pooled it
- Operative management of acute abdomen after bariatric surgery in the emergency setting: the OBA guidelines.World journal of emergency surgery : WJES · 2022Guideline
- Real-time endoscopic tissue oxygen saturation imaging of the upper gastrointestinal tract: baseline values and association with gastrojejunal anastomotic ulcer healing.Surgical endoscopy · 2026Article
- Early and Late Complications After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass: A Narrative Review.Journal of metabolic and bariatric surgery · 2026Review
- Remnant Gastrectomy as a Pathophysiology Based Treatment of Marginal Ulcer after Roux-en-Y Gastric Bypass: A Retrospective Clinical Series of 41 Patients.Obesity surgery · 2026Article
- Marginal Ulcers After Roux-en-Y Gastric Bypass: Patterns of Care, Treatment, and Outcomes from a Tertiary Referral Center.Obesity surgery · 2026Article
- A Comprehensive Analysis of Predictors of Marginal Ulcers After Roux-en-Y Gastric Bypass: A Cohort Review of 2106 Patients.Medicina (Kaunas, Lithuania) · 2026Article
- Incidence of marginal ulcer after one anastomosis gastric bypass versus Roux-en-Y gastric bypass: a comparative study.BMC surgery · 2026Article
- Surgical management of marginal ulcer sequelae after Roux-en-Y gastric bypass: a single-center retrospective cohort study.Surgical endoscopy · 2025Article
- Vagal-Sparing Versus Non-Vagal-Sparing Roux-en-Y Gastric Bypass: Complications and Weight Outcomes.Obesity surgery · 2025Article
- Endoscopic jejunal flap suturing for the treatment of refractory marginal ulcers-a case series.Surgical endoscopy · 2025Article
- Post Roux-en-Y Gastric Bypass Challenges: Gastrogastric Fistula After Marginal Ulcer Development.Obesity surgery · 2025Article
- Long-Term Results of Linear Versus Circular Stapled Gastrojejunostomy in Gastric Bypass Surgery: A Propensity Score-Adjusted Analysis of Weight Loss and Morbidity.Obesity surgery · 2025Article
- Experiencing Complications After Metabolic and Bariatric Surgeries is a Risk Factor for Postoperative Emergency Department Admissions: a Retrospective Cohort Study.Obesity surgery · 2025Observational
- Key techniques of laparoscopic RouxZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- More Anastomotic Ulcers, Less Dumping, and Equal Weight Loss in Long vs. Short Gastric Pouch in Laparoscopic Roux-en-Y Gastric Bypass.Obesity surgery · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMarginal ulcer formation is a known complication following RYGB. While most respond to medical therapy, many patients have recurrent or chronic MU. Although non-steroidal anti-inflammatory drug (NSAID) use, smoking and Helicobacter pylori infection are known risk factors of MU, little is known about what increases the likelihood of developing recalcitrant ulcers. The objective of this study is to identify risk factors for marginal ulcer (MU) formation, including recalcitrant ulcers requiring surgical revision, and to define the incidence and outcomes of revisional surgery.
methodsAll patients who underwent RYGB between 2011 and 2017 at a high-volume academic center were included. Patients with a postoperative diagnosis of MU were identified from the institution's bariatric database. Patient characteristics, operative data and surgical outcomes were analyzed using data collected in the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program and the Ontario Bariatric Registry.
resultsA total of 2830 RYGB were performed during the study period. The incidence of MU was 6.9% with 1% of patients requiring revisional surgery for a recalcitrant ulcer. Patients with a history of smoking (HR 5.03), immunosuppression (HR 4.60) and preoperative NSAID use (HR 3.11) were significantly more likely to develop a MU requiring surgical revision. Patients undergoing revision reported resolution of their symptoms in only 36% of cases with 57% developing a recurrent ulcer.
conclusionPatients with a history of smoking and use of immunosuppressive medication were at significantly higher risk of developing MU that failed medical therapy. Additional evidence is needed to inform perioperative management of bariatric patients.
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