Evidence map›Paper›PMID 32424605›Full record

ArticleInflammation2020

Anti-inflammatory Effect of Low-Dose Anethole and Ibuprofen Combination Is Accompanied by Partial Prevention of Hepatic Metabolic Changes in Arthritic Rats.

Franciele Queiroz Ames, Lívia Bracht, Larissa Carla Lauer Schneider, Bruno Ambrósio Rocha, Giovana Alves Santos, Emanuele Parreira Lima, Edvalkia Magna Teobaldo Rocha, Roberto Kenji Nakamura Cuman, Ciomar Aparecida Bersani-Amado

Abstract read
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In one paragraph

Article in Inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Franciele Queiroz AmesDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil.
Lívia BrachtDepartment of Biochemistry, State University of Maringá, Maringá, Paraná, Brazil.
Larissa Carla Lauer SchneiderDepartment of Morphological Sciences, State University of Maringá, Maringá, Paraná, Brazil.
Bruno Ambrósio RochaDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil.
Giovana Alves SantosDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil.
Emanuele Parreira LimaDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil.
Edvalkia Magna Teobaldo RochaDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil.
Roberto Kenji Nakamura CumanDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil.
Ciomar Aparecida Bersani-AmadoDepartment of Pharmacology and Therapeutics, State University of Maringá, Avenida Colombo, 5790, Maringá, Paraná, Brazil. cabamado@uem.br.ORCID http://orcid.org/0000-0002-0247-2090
Universidade Estadual de Maringá · BR

Funding

Fundação Araucária None
6 · The paper itself

Abstract

Anethole (AN) is a natural compound that has attracted great scientific interest because of its numerous biological activities, including anti-inflammatory effects. However, these effects were obtained with high doses of AN, which may be one limitation of its therapeutic use. This study evaluated the effects of a low-dose AN and ibuprofen (IB) combination on inflammatory parameters in Freund's complete adjuvant-induced arthritis (AIA) and arthritis-induced hepatic metabolic changes. Holtzman rats were used and divided into groups: normal, AIA (control), arthritics treated with IB, arthritics treated with AN, and arthritics treated with AN + IB. The volume of the paws, the appearance of secondary lesions, and the number of synovial leukocytes were evaluated. Gluconeogenesis and ureagenesis from alanine were determined in the rat liver in isolated perfusion. The AN + IB (62.5 + 8.75 mg/kg) treatment exerted an inhibitory effect on inflammatory parameters and partially prevented hepatic metabolic changes that was similar to the effect of high-dose IB (35 mg/kg) and AN (250 mg/kg) treatment. This effect of the treatments on hepatic metabolism can be, partly at least, explained by the preservation of both the alanine aminotransferase (ALT) activity and the cytosolic NADH/NAD

Indexed as

Allylbenzene DerivativesAnimalsAnisolesAnti-Inflammatory Agents, Non-SteroidalArthritis, ExperimentalDose-Response Relationship, DrugDrug Therapy, CombinationFreund's AdjuvantIbuprofenLiverMaleRatsRats, Sprague-DawleyAllylbenzene DerivativesanetholeAnisolesAnti-Inflammatory Agents, Non-SteroidalFreund's AdjuvantIbuprofenadjuvant-induced arthritisanetholeibuprofeninflammationliver metabolismnonsteroidal anti-inflammatory drug

Identifiers

PMID32424605
OpenAlexW3027792858

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.