Evidence map›Paper›PMID 32424573›Full record

ReviewJournal of neuro-oncology2020

Management of olfactory neuroblastoma, neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma involving the skullbase.

Gautam U Mehta, Shaan M Raza, Shirley Y Su, Ehab Y Hanna, Franco DeMonte

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Clinical, genetic and immunohistochemical characterization of sinonasal tumors with neuroectodermal differentiation.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Article
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  6. Review
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  8. Article
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  11. Endoscopic management of sinonasal tumours in the Nordic university hospitals: a survey.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  12. Review
  13. Sinonasal Neuroendocrine Carcinoma in Adult Proteus Syndrome.Iranian journal of otorhinolaryngology · 2023
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Gautam U MehtaDivision of Neurosurgery, House Clinic, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-8009-6430
Shaan M RazaDepartment of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Shirley Y SuDepartment of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Ehab Y HannaDepartment of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.
Franco DeMonteDepartment of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. fdemonte@mdanderson.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSinonasal tumors that harbor neuroendocrine histologic features include olfactory neuroblastoma (previously known as esthesioneuroblastoma), sinonasal neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. These tumors represent a diverse spectrum of clinical behavior and as such require histology-specific management. Herein, we review the management of these sinonasal tumors with neuroendocrine features and discuss fundamentals of multi-modality care for each histology. An emphasis is placed on olfactory neuroblastomas, given their relative frequency and skullbase origin.

methodsA comprehensive literature review on contemporary management of olfactory neuroblastoma, sinonasal neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma was performed.

resultsManagement of sinonasal tumors with neuroendocrine features can include surgical resection, radiation therapy, and/or chemotherapy. Due to their site of origin, these tumors can frequently involve the skullbase, which can require site-specific care. The optimal treatment modalities and the sequence in which they are performed are largely dependent on histology. In most cases, olfactory neuroblastoma is best managed with surgical resection followed by radiation therapy. Sinonasal neuroendocrine carcinomas represent a variety of histologic phenotypes (carcinoid, atypical carcinoid, small cell, and large cell), which determine the optimal treatment modality. Finally, sinonasal undifferentiated carcinoma is likely best managed by induction chemotherapy with subsequent therapy dictated by the initial response.

conclusionsA team approach to multi-modality care is essential in the treatment of olfactory neuroblastoma, sinonasal neuroendocrine carcinoma, and sinonasal undifferentiated carcinoma. Early biopsy, histologic diagnosis, and comprehensive imaging are critical to determining the appropriate management paradigm.

Indexed as

AnimalsCarcinomaCarcinoma, NeuroendocrineCombined Modality TherapyDisease ManagementEsthesioneuroblastoma, OlfactoryHumansMaxillary Sinus NeoplasmsNose NeoplasmsSkull Base NeoplasmsEsthesioneuroblastomaNeuroendocrine carcinomaOlfactory neuroblastomaSinonasal undifferentiated cancer

Identifiers

PMID32424573

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.