ArticleDiabetologia2020
Pregnancy loss is associated with type 2 diabetes: a nationwide case-control study.
Article in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Fetal loss and long-term maternal morbidity and mortality: A systematic review and meta-analysis.PLoS medicine · 2024Pooled it
- Assessing the efficacy and safety of SildenafilJournal of medicine and life · 2023Trial
- Association of spontaneous abortion and lifestyle with diabetes mellitus in women: a cross-sectional study in UK Biobank.BMC pregnancy and childbirth · 2025Article
- Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis.EClinicalMedicine · 2024Review
- "Translation, cultural adaptation, and validation of perinatal grief scale in Urdu: Addressing a gap in the research of perinatal loss in Pakistan-Cross-sectional validation study".Health science reports · 2024Article
- Risk factors associated with pregnancy loss after single euploid blastocysts transfer.Frontiers in endocrinology · 2024Article
- Pregnancy Loss and the Risk of Myocardial Infarction, Stroke, and All-Cause Mortality: A Nationwide Partner Comparison Cohort Study.Journal of the American Heart Association · 2023Article
- Previous pregnancy loss and gestational cardiovascular health: A prospective cohort of nulliparous women.Frontiers in public health · 2023Article
- Pregnancy loss and subsequent risk of prediabetes, diabetes and metabolic syndrome in couples: Tehran lipid and glucose study.Journal of translational medicine · 2022Article
- Diabetic and Hypertensive Disorders Following Miscarriage: A Protocol for Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Article
- H1299R Variant in Factor V and Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis Protocol.Genes · 2022Article
- Pregnancy loss and risk of multiple sclerosis and autoimmune neurological disorder: A nationwide cohort study.PloS one · 2022Article
- Pregnancy loss is related to body mass index and prediabetes in early adulthood: Findings from Add Health.PloS one · 2022Article
- Number of Births and Risk of Diabetes in China's Older Women.Frontiers in medicine · 2022Article
- Recurrent Pregnancy Loss and Concealed Long-QT Syndrome.Journal of the American Heart Association · 2021Article
- Maternal-foetal complications in pregnancy: a retrospective comparison between type 1 and type 2 diabetes mellitus.BMC pregnancy and childbirth · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
aims/hypothesisType 2 diabetes is killing more people than ever, and early-life predictors remain critical for the development of effective preventive strategies. Pregnancy loss is a common event associated with later atherosclerotic disease and ischaemic heart failure and might constitute a predictor for type 2 diabetes. The objective of this study was to investigate whether pregnancy loss is associated with later development of type 2 diabetes.
methodsUsing a Danish nationwide cohort, we identified all women born from 1957 through to 1997 and who had a diagnosis of type 2 diabetes during the period 1977 to 2017. The women were matched 1:10 on year of birth and educational level to women without diabetes in the general Danish population. Conditional logistic regression models provided odds ratios for type 2 diabetes with different numbers of pregnancy losses.
resultsWe identified 24,774 women with type 2 diabetes and selected 247,740 controls without diabetes. Women who had ever been pregnant (ever-pregnant women) with 1, 2 and ≥ 3 pregnancy losses had ORs of type 2 diabetes of 1.18 (95% CI 1.13, 1.23), 1.38 (95% CI 1.27, 1.49) and 1.71 (95% CI 1.53, 1.92) compared with ever-pregnant women with no pregnancy losses, respectively. Women who never achieved a pregnancy had an OR of type 2 diabetes of 1.56 (95% CI 1.51, 1.61) compared with ever-pregnant women with any number of losses. Similar results were found after adjustment for obesity and gestational diabetes. CONCLUSIONS/
interpretationWe found a significant and consistent association between pregnancy loss and later type 2 diabetes that increased with increasing number of losses. Thus, pregnancy loss and recurrent pregnancy loss are significant risk factors for later type 2 diabetes. Future studies should explore whether this association is due to common background factors or whether prediabetic metabolic conditions are responsible for this association. Graphical abstract.
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