Evidence map›Paper›PMID 32424460›Full record

ArticleClinical oral investigations2020

DNA double-strand breaks of human peripheral blood lymphocyte induced by CT examination of oral and maxillofacial region.

Pan Yang, Shuo Wang, Denggao Liu, Hua Zhao, Gang Li

Abstract read
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Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pan YangDepartment of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, #22 Zhongguancun Nandajie, Hai Dian District, Beijing, 100081, China.
Shuo WangDepartment of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, #22 Zhongguancun Nandajie, Hai Dian District, Beijing, 100081, China.
Denggao LiuDepartment of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, #22 Zhongguancun Nandajie, Hai Dian District, Beijing, 100081, China.
Hua ZhaoChina CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, 100088, People's Republic of China.
Gang LiDepartment of Oral and Maxillofacial Radiology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, #22 Zhongguancun Nandajie, Hai Dian District, Beijing, 100081, China. kqgang@bjmu.edu.cn.ORCID http://orcid.org/0000-0003-4642-2033

Funding

National Key R&D Program of China 2018 YFC0807303National Natural Science Foundation of China 81671034
6 · The paper itself

Abstract

objectivesTo explore whether a computed tomography (CT) examination of the head and neck region induces biological damage and whether the damage was correlated with the radiation dose. MATERIALS AND

methodsPeripheral blood was taken from 33 individuals who received head and neck CT examinations. Blood samples were divided into three groups: the control group and the in vivo and in vitro irradiation groups. The number of DNA double-strand breaks was estimated by comparing the changes in the rates of γ-H2AX foci formation in the peripheral blood before and after CT examination. The absorbed dose and effective dose were calculated with the software VirtualDose based on the Monte Carlo method, and the absorbed doses in blood were estimated accordingly.

resultsThe γ-H2AX foci rates were increased in the in vivo (p < 0.001) and in vitro irradiation groups (p < 0.001) after CT examination when compared with those in the control group. The rate of γ-H2AX foci formation showed linear dose-responses for the CT dose index volume (CTDI

conclusionsA CT examination of the head and neck region provides a high enough radiation dose to induce DNA double-strand breaks in cells in the peripheral blood. There was a linear correlation between the formation of DNA double-strand breaks and radiation doses after CT examination. CLINICAL RELEVANCE: In addition to ensuring image quality, in a real clinical situation, the scanning area should be strictly administered, and repeated operations should be avoided to minimise the patient's radiation dose.

Indexed as

DNA Breaks, Double-StrandedTomography, X-Ray ComputedDNADNA DamageHumansLymphocytesSoftwareDNADNA double-strand breakMultidetector computed tomographyRadiation dosageγ-H2AX

Identifiers

PMID32424460

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