ArticleClinical and experimental nephrology2020
Renal hypoplasia can be the cause of membranous nephropathy-like lesions.
Article in Clinical and experimental nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 4 citations in OpenAlex.
- Misdiagnosed Branchio-Oto-Renal syndrome presenting as proteinuria and renal insufficiency with insidious signs since early childhood: a report of three cases.BMC nephrology · 2023Article
- A girl with membranous nephropathy associated with ventriculoperitoneal shunt infection.CEN case reports · 2023Article
- Unilateral Kidney Agenesis and other Kidney Anomalies in Infertile Men with Congenital Bilateral Absence of Vas deferens: A Cross-Sectional Study.International journal of fertility & sterility · 2022Article
- Bilateral Renal Hypoplasia with High β2-Microglobulinuria in the Neonatal Period.The Kobe journal of medical sciences · 2021Article
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Authors and funding
12 authors at 3 institutions in 1 country.
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Abstract
backgroundRenal hypoplasia (RH) is the most common cause of chronic kidney disease in children. In cases of RH, proteinuria is often induced by glomerular hypertrophy and hyperfiltration that is commonly associated with focal segmental glomerulosclerosis. This study reports the first case series of a possible association between RH and membranous nephropathy (MN).
methodsOf the 168 children with RH who visited our department between 1999 and 2017, five with overt proteinuria (≥ 1 g/gCr) underwent renal biopsy. We retrospectively reviewed the medical charts and analyzed biopsy specimens using light microscopy (LM), immunofluorescence (IF), and electron microscopy.
resultsThe five children (four boys and one girl) had a median age of 5.5 years at the time of renal biopsy. The median proteinuria was 4.23 g/gCr (range 1.46-14.25), median serum albumin, 2.9 g/dL (range 2.3-3.7), and median estimated glomerular filtration rate, 59.7 mL/min/1.73 m
conclusionOur study suggests that RH can be the cause of MN-like lesions.
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