ArticleEye (London, England)2021
Serum metabolic signatures of high myopia among older Chinese adults.
Article in Eye (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomics facilitates the discovery of metabolic profiles and pathways for myopia: A systematic review.Eye (London, England) · 2023Pooled it
- Identifying potential therapeutic targets for high myopia via a case-control study and Mendelian randomisation analyses of the human blood metabolome.Eye (London, England) · 2026Article
- Article
- Integrative multi-omics identifies coordinated alterations in the gut microbiome and in plasma and aqueous humor metabolomes in high myopic cataract.Scientific reports · 2025Article
- Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Myopia and Metabolomics: A Comparative Study of Aqueous Humor and Serum Metabolites in Myopic Adults Undergoing Cataract Surgery.International journal of molecular sciences · 2025Article
- The potential role of amino acids in myopia: inspiration from metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Biomarkers: Promising Tools Towards the Diagnosis, Prognosis, and Treatment of Myopia.Journal of clinical medicine · 2024Review
- Metabolic Characteristics of Sclera in Lens-Induced Myopic Guinea Pigs.Investigative ophthalmology & visual science · 2024Article
- Gut microbiota-derived indole-3-acetic acid suppresses high myopia progression by promoting type I collagen synthesis.Cell discovery · 2024Article
- Glutathione and a Pool of Metabolites Partly Related to Oxidative Stress Are Associated with Low and High Myopia in an Altered Bioenergetic Environment.Antioxidants (Basel, Switzerland) · 2024Article
- Applications of artificial intelligence and bioinformatics methodologies in the analysis of ocular biofluid markers: a scoping review.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- Differences in change of post-operative antioxidant levels between laser-assisted lenticule extraction and femtosecond laser in situ keratomileusis.Journal of cellular and molecular medicine · 2024Article
- Metabolomics studies in common multifactorial eye disorders: a review of biomarker discovery for age-related macular degeneration, glaucoma, diabetic retinopathy and myopia.Frontiers in molecular biosciences · 2024Review
- Article
- Prevalent falls, fall frequencies and health-related quality of life among community-dwelling older Chinese adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2023Article
- Vitreous metabolomic signatures of pathological myopia with complications.Eye (London, England) · 2023Article
- Effects of Hypoxemia by Acute High-Altitude Exposure on Human Intestinal Flora and Metabolism.Microorganisms · 2023Article
- Metabolomic Profiling of Aqueous Humor from Pathological Myopia Patients with Choroidal Neovascularization.Metabolites · 2023Article
- Small molecule metabolites: discovery of biomarkers and therapeutic targets.Signal transduction and targeted therapy · 2023Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeHigh myopia is associated with blinding ocular morbidities. Identifying novel biomarkers may provide clues on pathogenic pathways that are currently unknown. We aimed to identify serum metabolic biomarkers and investigate the metabolic alterations in relation to high myopia.
methodsForty adults with high myopia and 40 with low myopia aged 60 years or older from the Weitang Geriatric Diseases study were included in the case-control study. Refractive error was determined by autorefraction followed by subjective refraction. We performed the metabolomic analysis of serum samples from patients with high myopia and age- and sex- matched controls with low myopia, using a nontargeted gas chromatography coupled to time-of-flight mass spectrometer. The area under the receiver operating characteristic curve (AUC) was computed to assess the discrimination capacities of each metabolite marker. Databases including KEGG and MetaboAnalyst were utilized to search for the potential pathways of metabolites.
resultsSerum metabolomic profiles could well distinguish high myopia from low myopia. Twenty metabolic biomarkers were identified as potential serum biomarkers for high myopia, yielding AUC values of 0.59-0.71. Metabolic pathways in relation to high myopia, mainly characterized by increased energy metabolism, increased oxidative stress, abnormal amino acid metabolism, and altered biotin metabolism, provide a foundation to support myopia progression.
conclusionsThis study identified valuable metabolic biomarkers and pathways that may facilitate an improved understanding of the disease pathogenesis. The finding holds translational value in the development of new therapeutic measures for high myopia-related complications.
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