ArticleCommunications biology2020
Macroscale and microcircuit dissociation of focal and generalized human epilepsies.
Article in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- Thalamic organization differentially contributes to clinical conditions in epilepsy.Communications medicine · 2026Article
- Mapping Individualized Dual-Axis Network Topology in Focal Epilepsy: Divergent Alterations in System Integrity, Integration, and Clinical Correlates.bioRxiv : the preprint server for biology · 2026Article
- Associations between epilepsy-related polygenic risk and brain morphology in childhood.Brain : a journal of neurology · 2026Article
- Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy.Nature communications · 2025Article
- High energy consumption characterizes abnormal brain state transitions in temporal lobe epilepsy.Neurobiology of disease · 2025Article
- Connectomes in Temporal Lobe and Idiopathic Generalized Epilepsies.Journal of clinical medicine · 2025Review
- Normative structural connectome constrains spreading transient brain activity in generalized epilepsy.BMC medicine · 2025Article
- A generalized epilepsy network derived from brain abnormalities and deep brain stimulation.Nature communications · 2025Article
- Brain Networks for Cortical Atrophy and Responsive Neurostimulation in Temporal Lobe Epilepsy.JAMA neurology · 2024Article
- Macroscale intrinsic dynamics are associated with microcircuit function in focal and generalized epilepsies.Communications biology · 2024Article
- Neurobehavioral and Clinical Comorbidities in Epilepsy: The Role of White Matter Network Disruption.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Functional and structural networks decoupling in generalized tonic-clonic seizures and its reorganization by drugs.Epilepsia open · 2023Article
- Altered Metabolic Networks in Mesial Temporal Lobe Epilepsy with Focal to Bilateral Seizures.Brain sciences · 2023Article
- Thalamostriatal disconnection underpins long-term seizure freedom in frontal lobe epilepsy surgery.Brain : a journal of neurology · 2023Article
- Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair.Communications biology · 2023Review
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Deep learning distinguishes connectomes from focal epilepsy patients and controls: feasibility and clinical implications.Brain communications · 2023Article
- Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy.Science advances · 2022Article
- Mahalanobis distance tractometry (MaD-Tract) - a framework for personalized white matter anomaly detection applied to TBI.NeuroImage · 2022Article
- Multimodal connectome biomarkers of cognitive and affective dysfunction in the common epilepsies.Network neuroscience (Cambridge, Mass.) · 2022Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 5 countries.
Funding
Abstract
Thalamo-cortical pathology plays key roles in both generalized and focal epilepsies, but there is little work directly comparing these syndromes at the level of whole-brain mechanisms. Using multimodal imaging, connectomics, and computational simulations, we examined thalamo-cortical and cortico-cortical signatures and underlying microcircuits in 96 genetic generalized (GE) and 107 temporal lobe epilepsy (TLE) patients, along with 65 healthy controls. Structural and functional network profiling highlighted extensive atrophy, microstructural disruptions and decreased thalamo-cortical connectivity in TLE, while GE showed only subtle structural anomalies paralleled by enhanced thalamo-cortical connectivity. Connectome-informed biophysical simulations indicated modest increases in subcortical drive contributing to cortical dynamics in GE, while TLE presented with reduced subcortical drive and imbalanced excitation-inhibition within limbic and somatomotor microcircuits. Multiple sensitivity analyses supported robustness. Our multiscale analyses differentiate human focal and generalized epilepsy at the systems-level, showing paradoxically more severe microcircuit and macroscale imbalances in the former.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.