ArticleNature communications2020
Functionally distinct high and low theta oscillations in the human hippocampus.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 229 citations in OpenAlex.
- Volitional learning promotes theta phase coding in the human hippocampus.Proceedings of the National Academy of Sciences of the United States of America · 2021Trial
- Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model.PLoS computational biology · 2026Article
- Integrating neural decoding, memristive materials, and adaptive control frameworks for next-generation hippocampal memory prosthetics.iScience · 2026Review
- Theta oscillations are an organizational unit of odor processing in the olfactory bulb.Science advances · 2026Article
- Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.Annual review of neuroscience · 2026Review
- The genetic signature of memory encoding along the human hippocampal axis.bioRxiv : the preprint server for biology · 2026Article
- Article
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Adaptive shifts in amygdala-hippocampal theta coupling govern aversive learning and extinction.Nature communications · 2026Article
- Hippocampal Long Axis Differentiation in Memory and Seizure Networks.Epilepsy currents · 2026Article
- Human neuronal firing varies with the frequency of local field potential oscillations.PLoS biology · 2026Article
- Article
- Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network.bioRxiv : the preprint server for biology · 2026Article
- Low-power analog and mixed-signal circuit techniques for next-generation miniature implantable neural interface systems.Biomedical engineering letters · 2026Review
- Evaluating place cell detection methods in Rats and Humans: Implications for cross-species spatial coding.PLoS computational biology · 2026Article
- Episodic memory encoding fluctuates at a theta rhythm of 3-10 Hz.Nature human behaviour · 2026Article
- Deciphering hippocampal place codes in weak theta rhythms.Nature communications · 2026Article
- Hippocampal-Prelimbic Coupling During Context-Dependent Extinction Retrieval in Rats.Hippocampus · 2026Article
- A proposal for realizing cognitive functions using traveling waves, phase-locked and synchronized patterns, holography, neural mixing, and single sideband communications.Frontiers in computational neuroscience · 2026Article
- Human neuronal firing is modulated by the frequency of local field potential oscillations.bioRxiv : the preprint server for biology · 2025Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 10 institutions in 1 country.
Funding
Abstract
Based on rodent models, researchers have theorized that the hippocampus supports episodic memory and navigation via the theta oscillation, a ~4-10 Hz rhythm that coordinates brain-wide neural activity. However, recordings from humans have indicated that hippocampal theta oscillations are lower in frequency and less prevalent than in rodents, suggesting interspecies differences in theta's function. To characterize human hippocampal theta, we examine the properties of theta oscillations throughout the anterior-posterior length of the hippocampus as neurosurgical subjects performed a virtual spatial navigation task. During virtual movement, we observe hippocampal oscillations at multiple frequencies from 2 to 14 Hz. The posterior hippocampus prominently displays oscillations at ~8-Hz and the precise frequency of these oscillations correlates with the speed of movement, implicating these signals in spatial navigation. We also observe slower ~3 Hz oscillations, but these signals are more prevalent in the anterior hippocampus and their frequency does not vary with movement speed. Our results converge with recent findings to suggest an updated view of human hippocampal electrophysiology. Rather than one hippocampal theta oscillation with a single general role, high- and low-frequency theta oscillations, respectively, may reflect spatial and non-spatial cognitive processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.