ArticleNature chemical biology2020
Plant terpenoid metabolism co-opts a component of the cell wall biosynthesis machinery.
Article in Nature chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 99 citations in OpenAlex.
- Coniferyl aldehyde from the phenylpropanoid pathway targets pyruvate kinase in Dactylobotrys graminicola to confer sheath rot resistance in hulless barley.Journal of integrative plant biology · 2026Article
- Complete biosynthesis of the clinical agent escin Ia.Nature communications · 2026Article
- Discovery and engineering of UDP-glycosyltransferase and its applications in natural sweetener glycosylation.World journal of microbiology & biotechnology · 2026Review
- Biased retention and functional diversification of CESA superfamily genes in Medicago mediating development and abiotic stress responses.BMC plant biology · 2026Article
- Complex engineering of Solanum alkaloids structural diversity in Nicotiana benthamiana.Plant biotechnology journal · 2026Article
- Enzymology and Structural Basis of Glycosyltransferases Involved in Saponin C28 Carboxylic AcidJACS Au · 2025Article
- Unveiling the catalytical roles of three glycosyltransferases in triterpenoid saponins in quinoa.Plant biotechnology journal · 2025Article
- Glycyrrhiza, a commonly used medicinal herb: Review of species classification, pharmacology, active ingredient biosynthesis, and synthetic biology.Journal of advanced research · 2025Review
- A substrate-multiplexed platform for profiling enzymatic potential of plant family 1 glycosyltransferases.Nature communications · 2025Article
- Enzymatic twists evolved stereo-divergent alkaloids in the Solanaceae family.Nature communications · 2025Article
- Harnessing Apple Cell Suspension Cultures in Bioreactors for Triterpene Production: Transcriptomic Insights into Biomass and Triterpene Biosynthesis.International journal of molecular sciences · 2025Article
- Navigating the challenges of engineering composite specialized metabolite pathways in plants.The Plant journal : for cell and molecular biology · 2025Review
- Unlocking saponin biosynthesis in soapwort.Nature chemical biology · 2025Article
- In planta ectopic expression of two subtypes of tomato cellulose synthase-like M genes affects cell wall integrity and supports a role in arabinogalactan and/or rhamnogalacturonan-I biosynthesis.Plant & cell physiology · 2025Article
- A GAME changer in steroidal metabolite biosynthesis.Plant communications · 2025Article
- Incorporation of nitrogen in antinutritional Solanum alkaloid biosynthesis.Nature chemical biology · 2025Article
- Triterpene RDF: Developing a database of plant enzymes and transcription factors involved in triterpene biosynthesis using the Resource Description Framework.Plant biotechnology (Tokyo, Japan) · 2024Article
- Synthetic biology in plants.Plant biotechnology (Tokyo, Japan) · 2024Article
- Advances in Engineering Nucleotide Sugar Metabolism for Natural Product Glycosylation inACS synthetic biology · 2024Review
- Classification, biosynthesis, and biological functions of triterpene esters in plants.Plant communications · 2024Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glycosylation is one of the most prevalent molecular modifications in nature. Single or multiple sugars can decorate a wide range of acceptors from proteins to lipids, cell wall glycans and small molecules, dramatically affecting their activity. Here, we discovered that by 'hijacking' an enzyme of the cellulose synthesis machinery involved in cell wall assembly, plants evolved cellulose synthase-like enzymes (Csls) and acquired the capacity to glucuronidate specialized metabolites, that is, triterpenoid saponins. Apparently, endoplasmic reticulum-membrane localization of Csls and of other pathway proteins was part of evolving a new glycosyltransferase function, as plant metabolite glycosyltransferases typically act in the cytosol. Discovery of glucuronic acid transferases across several plant orders uncovered the long-pursued enzymatic reaction in the production of a low-calorie sweetener from licorice roots. Our work opens the way for engineering potent saponins through microbial fermentation and plant-based systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.