ArticleNature neuroscience2020
General anesthetics activate a potent central pain-suppression circuit in the amygdala.
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
89 citing papers in PubMed, 163 citations in OpenAlex.
- Anesthesia unconsciousness recruits dynamic parabrachial activity within a distributed brain-wide ensemble.bioRxiv : the preprint server for biology · 2026Article
- Distinct Role of Specialized Cutaneous Schwann Cell Network in Acute and Chronic Pain Sensation.Neuroscience bulletin · 2026Article
- A brainstem pathway underlying vagal modulation of somatic pain and affective states.Nature neuroscience · 2026Article
- 40 Hz light flickering alleviates chronic pain via adenosine signaling in the retina-amygdala pathway.Cell research · 2026Article
- Central amygdalar PKCδ neurons mediate fentanyl withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Amygdalar calcitonin gene-related peptide driven effects of cold sensitivity induced by peripheral neuropathy in mice.The journal of pain · 2026Article
- Edinger-Westphal Neurons Contribute to Emergence from Desflurane and Sevoflurane Anesthesia in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Effects of electroacupuncture at Zusanli on pain-perception-related brain nuclei in KOA mice: a study on cortical and subcortical c-fos expression.Behavioral and brain functions : BBF · 2026Article
- Immunoreactivity and distribution of Fos in the mouse brain following diverse general anesthetics.Scientific reports · 2025Article
- Preclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.The journal of pain · 2025Review
- Ketamine Evokes Acute Behavioral Effects Via μ Opioid Receptor-Expressing Neurons of the Central Amygdala.Biological psychiatry · 2025Article
- The posterior capsular central amygdala showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice.iScience · 2025Article
- The Effect of Pexidartinib on Neuropathic Pain via Influences on Microglia and Neuroinflammation in Mice.Anesthesia and analgesia · 2025Article
- Regulation of PVT-CeA Circuit in Deoxynivalenol-Induced Anorexia and Aversive-Like Emotions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cerebellar Bergmann glia integrate noxious information and modulate nocifensive behaviors.Nature neuroscience · 2025Article
- Web Application for Simulation of an Agent-Based Model in NetLogo3D.Spora : a journal of biomathematics · 2025Article
- Anesthetic- and Analgesic-Related Drugs Modulating Both Voltage-Gated NaBiomolecules · 2024Review
- Neural Network Mechanisms Underlying General Anesthesia: Cortical and Subcortical Nuclei.Neuroscience bulletin · 2024Review
- General anesthesia activates a central anxiolytic center in the BNST.Cell reports · 2024Article
- Harnessing Miniscope Imaging in Freely Moving Animals to Unveil Migraine Pathophysiology and Validate Novel Therapeutic Strategies.Synapse (New York, N.Y.) · 2024Review
29 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
General anesthesia (GA) can produce analgesia (loss of pain) independent of inducing loss of consciousness, but the underlying mechanisms remain unclear. We hypothesized that GA suppresses pain in part by activating supraspinal analgesic circuits. We discovered a distinct population of GABAergic neurons activated by GA in the mouse central amygdala (CeA
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.