ArticleNature neuroscience2020
Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 114 papers.
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114citing papers in PubMed
10.5field-weighted citation impact, top 1% of its field
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Who cites it
114 citing papers in PubMed, 166 citations in OpenAlex.
- Astrocyte-derived LAMC1 protects against intracerebral hemorrhage: A novel genetic mechanism maintaining neurovascular integrity.Journal of advanced research · 2026Article
- The YTHDF proteins modulate Alzheimer's disease-associated brain gene signatures.Molecular neurodegeneration · 2026Article
- Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson's disease.Research square · 2026Article
- Integrating dorsolateral prefrontal cortex multi-omics and GWAS summary data reveals genetic etiology of Parkinson's disease.medRxiv : the preprint server for health sciences · 2026Article
- Integration of Brain Proteomes and Genome-Wide Association Data Identifies GLO1 as a Candidate Causal Gene and Therapeutic Target for Restless Legs Syndrome.International journal of molecular sciences · 2026Article
- Cell-type-aware transcriptome-wide association studies identify 91 independent risk genes for Alzheimer's disease dementia.Communications biology · 2026Article
- Multiblock proteomic profiling identifies novel biomarkers linking prediabetes with preclinical atherosclerosis in apparently healthy adults.Cardiovascular diabetology · 2026Article
- Atractylenolide I mitigates Alzheimer's disease pathology in ApoEActa biochimica et biophysica Sinica · 2026Article
- Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026Article
- CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the treatment of Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Tau oligomers modulate synapse fate by eliciting progressive bipartite synapse dysregulation and synapse loss.Molecular neurodegeneration · 2026Article
- CSF Proteomics and Machine Learning Reveal Distinct Stages Across the Alzheimer's Disease Continuum.medRxiv : the preprint server for health sciences · 2025Article
- Region-specific proteomic analysis of aging rhesus macaques following chronic glutamate-carboxypeptidase-II (GCPII) inhibition elucidates potential treatment strategies for sporadic Alzheimer's disease.bioRxiv : the preprint server for biology · 2025Article
- Integrative Genetic, Proteogenomic, and Multi-omics Analyses Reveal Sex-Biased Causal Genes and Drug Targets in Alzheimer's Disease.medRxiv : the preprint server for health sciences · 2025Article
- Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Combined multi-omics and brain pathology reveal novel biomarkers for alzheimer's disease.Scientific reports · 2025Article
- Interplay between age, APOE Ɛ4 and the metabolome in plasma and brain in Alzheimer's disease.Translational psychiatry · 2025Article
- Late-onset alzheimer's disease, atherosclerosis, and cerebrovascular disease. A complex relationship too often neglected: a narrative review.Aging clinical and experimental research · 2025Review
- Cerebrospinal fluid proteomics for predictive assessment of Alzheimer's Disease risk.medRxiv : the preprint server for health sciences · 2025Article
- Current perspectives on the pathogenesis of cerebral atherosclerosis.Journal of inflammation (London, England) · 2025Review
54 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
18 authors at 4 institutions in 1 country.
Aliza P WingoDivision of Mental Health, Atlanta VA Medical Center, Decatur, GA, USA. aliza.wingo@emory.edu.ORCID http://orcid.org/0000-0002-6360-6726
Wen FanDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Duc M DuongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.
Ekaterina S GerasimovDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Eric B DammerDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-2947-7606
Yue LiuDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Nadia V HarerimanaDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
Bartholomew WhiteDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Madhav ThambisettyClinical and Translational Neuroscience Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Juan C TroncosoDepartment of Pathology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Namhee KimRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Julie A SchneiderRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Ihab M HajjarDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
James J LahDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.
Nicholas T SeyfriedDepartment of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA. nseyfri@emory.edu.ORCID http://orcid.org/0000-0002-4507-624X
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA. alevey@emory.edu.ORCID http://orcid.org/0000-0002-3153-502X
Thomas S WingoDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, USA. thomas.wingo@emory.edu.ORCID http://orcid.org/0000-0002-7679-6282
Emory University · USRush University Medical Center · USJohns Hopkins University · USNational Institutes of Health · US
Funding
Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2014 to 2026
$51.5MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BARNES, LISA L · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 1985 to 2019
$37.6MResearch Education ComponentP30AG066507 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2020 to 2026
$29.3MThe Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0MThe Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WALKER, LARY C · 2005 to 2019
$25.7MRISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF ADR01AG015819 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1998 to 2024
$21.4MMulti-omic network-directed proteoform discovery, dissection and functional validation to prioritize novel AD therapeutic targetsU01AG061356 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2018 to 2022
$13.7MPathway discovery, validation and compound identification for Alzheimer's disease - SupplementU01AG046152 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BENNETT, DAVID ALAN, DE JAGER, PHILIP L · 2013 to 2017
$13.6MUnderstanding mechanisms and seeking novel biomarkers in Alzheimer's diseaseZIAAG000200 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2013 to 2024
$12.2MSupplement to AMP-AD Brain Proteomic Network Enhancement, Validation and Translation into CSF BiomarkersU01AG061357 · NIA · EMORY UNIVERSITY · PI LEVEY, ALLAN I, SEYFRIED, NICHOLAS THOMAS · 2018 to 2022
$9.1MBLRD VA I01 BX003853NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066511NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG025688NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG053960NIA NIH HHS R01 AG056533NIA NIH HHS R01 AG057911NIA NIH HHS R01 AG061800NIA NIH HHS R01 AG064233NIA NIH HHS R21 AG055844NIA NIH HHS R56 AG060757NIA NIH HHS R56 AG062256NIA NIH HHS R56 AG062633NIA NIH HHS RC2 AG036547NIA NIH HHS RF1 AG057470NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG046161NIA NIH HHS U01 AG061356NIA NIH HHS U01 AG061357NIA NIH HHS U19 AG033655NIMH NIH HHS R01 MH117292NIMH NIH HHS U01 MH115484NINDS NIH HHS P30 NS055077
Abstract
Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development and myelination. Consistently, single-cell RNA sequencing showed cerebral atherosclerosis associated with higher oligodendrocyte abundance. A subset of proteins and modules associated with cerebral atherosclerosis was also associated with Alzheimer's disease, suggesting shared mechanisms.
Indexed as
ProteomicsAgingAlzheimer DiseaseDatabases, FactualHumansIntracranial ArteriosclerosisNerve Tissue ProteinsPrefrontal CortexNerve Tissue Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.