Evidence map›Paper›PMID 32424236›Full record

ArticleMolecular psychiatry2021

Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group.

Laura K M Han, Richard Dinga, Tim Hahn, Christopher R K Ching, Lisa T Eyler, Lyubomir Aftanas, Moji Aghajani, André Aleman, Bernhard T Baune, Klaus Berger and 136 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
198citing papers in PubMed, 8 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

198 citing papers in PubMed, 8 syntheses or guidelines pooled it, 296 citations in OpenAlex.

  1. Pooled it
  2. BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024
    Pooled it
  3. Pooled it
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  7. Pooled it
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  9. Trial
  10. Trial
  11. Article
  12. Integration of neuroimaging signatures of aging and Alzheimer's with fluid biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  13. Article
  14. Article
  15. Neonatal brain-age models in full- and preterm infants.Developmental cognitive neuroscience · 2026
    Article
  16. Article
  17. Article
  18. Lifestyle and BrainAGE in adult depression.Translational psychiatry · 2026
    Article
  19. Article
  20. Article

138 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

146 authors at 20 institutions in 15 countries.

Laura K M HanDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands. l.han@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-9647-3723
Richard DingaDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands.
Tim HahnDepartment of Psychiatry, University of Münster, Münster, Germany.
Christopher R K ChingImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Lisa T EylerDesert-Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-7783-8798
Lyubomir AftanasFSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia.
Moji AghajaniDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands.
André AlemanDepartment of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Bernhard T BauneDepartment of Psychiatry, University of Münster, Münster, Germany.
Klaus BergerInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ivan BrakFSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia.ORCID http://orcid.org/0000-0002-5146-0096
Geraldo Busatto FilhoLaboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Angela CarballedoDepartment for Psychiatry, Trinity College Dublin, Dublin, Ireland.
Colm G ConnollyDepartment of Biomedical Sciences, Florida State University, Tallahassee, FL, USA.
Baptiste Couvy-DuchesneInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Kathryn R CullenDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Udo DannlowskiDepartment of Psychiatry, University of Münster, Münster, Germany.
Christopher G DaveyOrygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0003-1431-3852
Danai DimaDepartment of Psychology, School of Arts and Social Sciences, City, University of London, London, UK.
Fabio L S DuranLaboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-7603-6152
Verena EnnekingDepartment of Psychiatry, University of Münster, Münster, Germany.
Elena FilimonovaFSSBI "Scientific Research Institute of Physiology & Basic Medicine", Laboratory of Affective, Cognitive & Translational Neuroscience, Novosibirsk, Russia.
Stefan FrenzelDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Thomas FrodlDepartment for Psychiatry, Trinity College Dublin, Dublin, Ireland.
Cynthia H Y FuCentre for Affective Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Beata R GodlewskaDepartment of Psychiatry, University of Oxford, Oxford, UK.
Ian H GotlibDepartment of Psychology, Stanford University, Stanford, CA, USA.
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
Nynke A GroenewoldInterdisciplinary Center Psychopathology and Emotion regulation (ICPE), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Dominik GrotegerdDepartment of Psychiatry, University of Münster, Münster, Germany.
Oliver GruberSection for Experimental Psychopathology and Neuroimaging, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany.
Geoffrey B HallDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.
Ben J HarrisonMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, VIC, Australia.
Sean N HattonYouth Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9149-8726
Marco HermesdorfInstitute of Epidemiology and Social Medicine, University of Münster, Münster, Germany.
Ian B HickieYouth Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Tiffany C HoDepartment of Psychology, Stanford University, Stanford, CA, USA.
Norbert HostenDepartment of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Andreas JansenDepartment of Psychiatry, Philipps-University Marburg, Marburg, Germany.
Claas KählerDepartment of Psychiatry, University of Münster, Münster, Germany.
Tilo KircherDepartment of Psychiatry, Philipps-University Marburg, Marburg, Germany.
Bonnie Klimes-DouganDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Bernd KrämerSection for Experimental Psychopathology and Neuroimaging, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany.
Axel KrugDepartment of Psychiatry, Philipps-University Marburg, Marburg, Germany.
Jim LagopoulosYouth Mental Health Team, Brain and Mind Centre, University of Sydney, Sydney, NSW, Australia.
Ramona LeeningsDepartment of Psychiatry, University of Münster, Münster, Germany.
Frank P MacMasterDepartments of Psychiatry and Pediatrics, University of Calgary, Calgary, AB, Canada.
Glenda MacQueenDepartment of Psychiatry, University of Calgary, Calgary, AB, Canada.
Andrew McIntoshDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-0198-4588
Quinn McLellanDepartments of Psychiatry and Pediatrics, University of Calgary, Calgary, AB, Canada.
Katie L McMahonSchool of Clinical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-6357-615X
Sarah E MedlandQIMR Berghofer Medical Research Instititute, Brisbane, QLD, Australia.
Bryon A MuellerDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.ORCID http://orcid.org/0000-0003-2429-0391
Benson MwangiDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Evgeny OsipovLaboratory of Experimental & Translational Neuroscience, Novosibirsk State University, Novosibirsk, Russia.ORCID http://orcid.org/0000-0002-4961-296X
Maria J PortellaInstitut d'Investigació Biomèdica Sant Pau, Barcelona, Catalonia, Spain.
Elena PozziDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Liesbeth RenemanDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Jonathan ReppleDepartment of Psychiatry, University of Münster, Münster, Germany.
Pedro G P RosaLaboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Matthew D SacchetCenter for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
Philipp G SämannMax Planck Institute of Psychiatry, Munich, Germany.
Knut SchnellDepartment of Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Anouk SchranteeDepartment of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Egle SimulionyteDepartment of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.
Jair C SoaresDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Jens SommerDepartment of Psychology, University of Minnesota, Minneapolis, MN, USA.
Dan J SteinDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7218-7810
Olaf SteinsträterDepartment of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.
Lachlan T StrikeQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-2885-5898
Sophia I ThomopoulosImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Marie-José van TolCognitive Neuroscience Center, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-9260-5490
Ilya M VeerDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert R J M VermeirenDepartment of Child Psychiatry, University Medical Center, Leiden, The Netherlands.
Henrik WalterDivision of Mind and Brain Research, Department of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Nic J A van der WeeLeiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
Steven J A van der WerffLeiden Institute for Brain and Cognition, Leiden University, Leiden, The Netherlands.
Heather WhalleyDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-4505-8869
Nils R WinterDepartment of Psychiatry, University of Münster, Münster, Germany.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-4383-5043
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Mon-Ju WuDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0540-8027
Henry VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Tony T YangDepartment of Psychiatry, Division of Child and Adolescent Psychiatry, UCSF School of Medicine, UCSF, San Francisco, CA, USA.
Vasileios ZanniasDivision of Psychiatry, University of Edinburgh, Edinburgh, UK.
Greig I de ZubicarayInstitute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-4506-0579
Giovana B Zunta-SoaresDepartment of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Christoph AbéDepartment of Clinical Neuroscience, Osher Center, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1680-8480
Martin AldaDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.ORCID http://orcid.org/0000-0001-9544-3944
Ole A AndreassenNORMENT Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Erlend BøenClinic for Mental Health and Dependency, C-L psychiatry and Psychosomatic Unit, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0002-9546-2763
Caterina M BonninHospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Erick J Canales-RodriguezFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Catalonia, Spain.
Dara CannonCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33, Galway, Ireland.ORCID http://orcid.org/0000-0001-7378-3411
Xavier CaserasMRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-8490-6891
Tiffany M Chaim-AvanciniLaboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Torbjørn ElvsåshagenNorwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Pauline FavreUNIACT, Psychiatry Team, Neurospin, Atomic Energy Commission, Gif-Sur-Yvette, France.
Sonya F FoleyCardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, UK.ORCID http://orcid.org/0000-0002-8390-2709
Janice M FullertonNeuroscience Research Australia, Randwick, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4014-4490
Jose M GoikoleaHospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Bartholomeus C M HaarmanDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-9006-8863
Tomas HajekDepartment of Psychiatry, Dalhousie University, Halifax, NS, Canada.
Chantal HenryUniversité de Paris, Service Hospitalo-Universitaire, GHU Paris Psychiatrie & Neuroscience, F-75014, Paris, France.
Josselin HouenouUNIACT, Psychiatry Team, Neurospin, Atomic Energy Commission, Gif-Sur-Yvette, France.ORCID http://orcid.org/0000-0003-3166-5606
Fleur M HowellsDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Martin IngvarDepartment of Clinical Neuroscience, Osher Center, Karolinska Institutet, Stockholm, Sweden.
Rayus KuplickiLaureate Institute for Brain Research, Tulsa, OK, USA.
Beny LaferDepartment of Psychiatry, School of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil.
Mikael LandénDepartment of Clinical Neuroscience, Osher Center, Karolinska Institutet, Stockholm, Sweden.
Rodrigo Machado-VieiraDepartment of Psychiatry, School of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil.ORCID http://orcid.org/0000-0002-4830-1190
Ulrik F MaltDepartment of Clinical Neuroscience, University of Oslo, Oslo, Norway.ORCID http://orcid.org/0000-0002-9881-2511
Colm McDonaldCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33, Galway, Ireland.ORCID http://orcid.org/0000-0003-1661-5192
Philip B MitchellSchool of Psychiatry, University of New South Wales, Kingsford, Sydney, NSW, Australia.
Leila NabulsiCentre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33, Galway, Ireland.ORCID http://orcid.org/0000-0001-9448-7769
Maria Concepcion Garcia OtaduyInstituto de Radiologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Bronwyn J OversNeuroscience Research Australia, Randwick, Sydney, NSW, Australia.
Mircea PolosanDepartment of Psychiatry and Neurology, CHU Grenoble Alpes, Université Grenoble Alpes, F-38000, Grenoble, France.
Edith Pomarol-ClotetFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Catalonia, Spain.
Joaquim RaduaHospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Maria M RiveDepartment of Psychiatry, Amsterdam University Medical Centers, AMC, Amsterdam, The Netherlands.
Gloria RobertsSchool of Psychiatry, University of New South Wales, Kingsford, Sydney, NSW, Australia.
Henricus G RuheDonders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Raymond SalvadorFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Catalonia, Spain.
Salvador SarróFIDMAG Germanes Hospitalàries Research Foundation, CIBERSAM, Barcelona, Catalonia, Spain.
Theodore D SatterthwaiteDepartment of Psychiatry, University of Pennsylvannia Perelman School of Medicine, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7072-9399
Jonathan SavitzLaureate Institute for Brain Research, Tulsa, OK, USA.
Aart H ScheneDonders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
Peter R SchofieldNeuroscience Research Australia, Randwick, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Mauricio H SerpaLaboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.ORCID http://orcid.org/0000-0001-9384-5587
Kang SimWest Region and Research Division, Institute of Mental Health, Singapore, Singapore.
Marcio Gerhardt Soeiro-de-SouzaDepartment of Psychiatry, School of Medicine, University of Sao Paulo (FMUSP), Sao Paulo, Brazil.ORCID http://orcid.org/0000-0002-9293-3128
Ashley N SutherlandDepartment of Psychiatry, University of California San Diego, Los Angeles, CA, USA.
Henk S TemminghSection for Experimental Psychopathology and Neuroimaging, Department of Psychiatry, University of Heidelberg, Heidelberg, Germany.
Garrett M TimmonsDepartment of Psychiatry, University of California San Diego, Los Angeles, CA, USA.
Anne UhlmannDepartment of Psychiatry and Neuroscience Institute, University of Cape Town, Cape Town, South Africa.
Eduard VietaHospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
Daniel H WolfDepartment of Psychiatry, University of Pennsylvannia Perelman School of Medicine, Philadelphia, PA, USA.
Marcus V ZanettiLaboratory of Psychiatric Neuroimaging (LIM-21), Instituto de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil.
Neda JahanshadImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0003-4401-8950
Paul M ThompsonImaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Dick J VeltmanDepartment of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands.
Brenda W J H Penninx *Department of Psychiatry, Amsterdam Public Health and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit & GGZinGeest, Amsterdam, The Netherlands.
Andre F Marquand *Donders Institute for Brain, Cognition and Behavior, Radboud University, Nijmegen, The Netherlands.
James H Cole *Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College, London, UK.ORCID http://orcid.org/0000-0003-1908-5588
Lianne Schmaal *Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, VIC, Australia.
University of Münster · DEHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversitätsmedizin Greifswald · DECentro de Investigación Biomédica en Red de Salud Mental · ESThe University of Melbourne · AUAmsterdam Neuroscience · NLHospital Mare de Déu de la Mercè · ESOslo University Hospital · NORadboud University Nijmegen · NLThe University of Texas Health Science Center at Houston · USUniversity Medical Center Groningen · NLUniversity of Southern California · USAmsterdam University Medical Centers · NLHeidelberg University · DEInserm · FRKarolinska Institutet · SELeiden University · NLNovosibirsk State University · RUOllscoil na Gaillimhe – University of Galway · IEThe University of Queensland · AU

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)P20GM121312 · NIGMS · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI Jonathan Savitz · 2017 to 2026
$23.7M
ZOOMED FUNCT IMAGING IN HUMAN BRAIN AT 7T W/ SIMULT HIGH SPATIAL &TEMPORAL RESP41RR008079 · NCRR · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUBINSKY, JANET M · 1993 to 2011
$16.3M
TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VAN HORN, JOHN DARRELL · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Psychobiological Mechanisms Underlying the Association Between Early Life Stress and Depression Across AdolescenceR37MH101495 · NIMH · STANFORD UNIVERSITY · PI IAN H GOTLIB · 2018 to 2026
$6.6M
High resolution mapping of the genetic risk for disease in the aging brainR01AG059874 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI JAHANSHAD, NEDA · 2018 to 2022
$3.1M
Growth factors, neuroinflammation, exercise, and brain integrityRF1AG041915 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2014
$2.9M
Multi-Source Sparse Learning to Identify MCI and Predict DeclineRF1AG051710 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THOMPSON, PAUL M, WANG, YALIN · 2016 to 2016
$2.8M
A Cross-Sectional and Longitudinal Functional MRI Study of Adolescent DepressionR01MH085734 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YANG, TONY TUNG-I · 2010 to 2014
$2.7M
Genetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6M
ENIGMA-SD: Understanding Sex Differences in Global Mental Health through ENIGMAR01MH116147 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2021
$2.5M
Department of HealthMedical Research Council G0802594Medical Research Council MR/L010305/1Medical Research Council MR/R024790/2NCATS NIH HHS UL1 TR001872NCCIH NIH HHS R21 AT009173NCCIH NIH HHS R61 AT009864NCRR NIH HHS P41 RR008079NIA NIH HHS R01 AG059874NIA NIH HHS R56 AG058854NIA NIH HHS RF1 AG041915NIA NIH HHS RF1 AG051710NIA NIH HHS T32 AG058507NIA NIH HHS T35 AG026757NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NICHD NIH HHS R01 HD050735NIGMS NIH HHS P20 GM121312NIMH NIH HHS K01 MH117442NIMH NIH HHS K23 MH090421NIMH NIH HHS R01 MH083968NIMH NIH HHS R01 MH085734NIMH NIH HHS R01 MH116147NIMH NIH HHS R01 MH117601NIMH NIH HHS R21 MH113871NIMH NIH HHS R37 MH101495NIMH NIH HHS T32 MH073526Wellcome TrustWellcome Trust 104036/Z/14/Z
6 · The paper itself

Abstract

Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18-75 years) from 7 subcortical volumes, 34 cortical thickness and 34 surface area, lateral ventricles and total intracranial volume measures separately in 952 male and 1236 female controls from the ENIGMA MDD working group. The learned model coefficients were applied to 927 male controls and 986 depressed males, and 1199 female controls and 1689 depressed females to obtain independent unbiased brain-based age predictions. The difference between predicted "brain age" and chronological age was calculated to indicate brain-predicted age difference (brain-PAD). On average, MDD patients showed a higher brain-PAD of +1.08 (SE 0.22) years (Cohen's d = 0.14, 95% CI: 0.08-0.20) compared with controls. However, this difference did not seem to be driven by specific clinical characteristics (recurrent status, remission status, antidepressant medication use, age of onset, or symptom severity). This highly powered collaborative effort showed subtle patterns of age-related structural brain abnormalities in MDD. Substantial within-group variance and overlap between groups were observed. Longitudinal studies of MDD and somatic health outcomes are needed to further assess the clinical value of these brain-PAD estimates.

Indexed as

Major Depressive DisorderAdolescentAdultAgedAgingBrainFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedYoung Adult

Identifiers

PMID32424236
PMCPMC8589647
OpenAlexW3024838586

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