Evidence map›Paper›PMID 32424171›Full record

ArticleScientific reports2020

Cyclin D2-knock-out mice with attenuated dentate gyrus neurogenesis have robust deficits in long-term memory formation.

Stela P Petkova, Michael Pride, Carolyn Klocke, Timothy A Fenton, Jeannine White, Pamela J Lein, Jacob Ellegood, Jason P Lerch, Jill L Silverman, Ben Waldau

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. New neurons flatten social hierarchies.Scientific reports · 2026
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Stela P Petkova *Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, 95817, US.
Michael Pride *Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, 95817, US.
Carolyn KlockeDepartment of Molecular Biosciences, UC Davis School of Veterinary Medicine, Davis, CA, 95616, US.
Timothy A FentonDepartment of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, 95817, US.
Jeannine WhiteInstitute for Regenerative Cures, Sacramento, CA, 95817, US.
Pamela J LeinDepartment of Molecular Biosciences, UC Davis School of Veterinary Medicine, Davis, CA, 95616, US.
Jacob EllegoodMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, M5T 3H7, Canada.
Jason P LerchMouse Imaging Centre, Hospital for Sick Children, Toronto, Ontario, M5T 3H7, Canada.
Jill L SilvermanDepartment of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine, Sacramento, CA, 95817, US.
Ben WaldauDepartment of Neurological Surgery, UC Davis Medical Center, Sacramento, CA, 95817, US. bwaldau@ucdavis.edu.
University of California, Davis · USCalifornia Institute for Regenerative Medicine · USHospital for Sick Children · CANeurological Surgery · USWellcome Centre for Integrative Neuroimaging · GB

Funding

Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI VAN DE WATER, JUDY A. · 2013 to 2019
$8.5M
Phenotypic Characterization of Novel Models of Dup15q SyndromeR01NS097808 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SILVERMAN, JILL LYNN · 2017 to 2021
$1.7M
NICHD NIH HHS U54 HD079125NINDS NIH HHS R01 NS097808
6 · The paper itself

Abstract

Neurobehavioral studies have produced contradictory findings concerning the function of neurogenesis in the adult dentate gyrus. Previous studies have proved inconsistent across several behavioral endpoints thought to be dependent on dentate neurogenesis, including memory acquisition, short-term and long-term retention of memory, pattern separation, and reversal learning. We hypothesized that the main function of dentate neurogenesis is long-term memory formation because we assumed that a newly formed and integrated neuron would have a long-term impact on the local neural network. We used a cyclin D2-knock-out (cyclin D2

Indexed as

Memory, Long-TermNeurogenesisAnimalsCyclin D2Dentate GyrusFemaleMaleMaze LearningMemory, Short-TermMiceMice, Inbred C57BLMice, KnockoutNeuronsCyclin D2

Identifiers

PMID32424171
PMCPMC7235216
OpenAlexW3024890451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.