ArticleScientific reports2020
Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 47 citations in OpenAlex.
- Lactobacillus Fermentum MCC2760 Mitigates Oxidized Oil-Induced Metabolic Dysfunction and Gut-liver axis Perturbations: A Two-Generation Study in rats.Probiotics and antimicrobial proteins · 2026Article
- Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment.Journal of translational medicine · 2026Review
- Prolonged Antibiotic Exposure During Gestation Increases the Severity of Perinatal Asphyxia as Measured by EEG Reactivity in Rodents.Neurology international · 2026Article
- Early-life maternal probiotic supplementation programs sex- and region-specific gene expression in the adult offspring brain.Brain, behavior, & immunity - health · 2026Article
- Early-life gut microbiome maturity regulates blood-brain barrier and cognitive development.Gut microbes · 2025Article
- How the gut microbiome shapes learning and memory: A comprehensive review.IBRO neuroscience reports · 2025Review
- Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?Antioxidants (Basel, Switzerland) · 2025Review
- Basic biology and roles of CEBPD in cardiovascular disease.Cell death discovery · 2025Review
- Interactions of the maternal microbiome with diet, stress, and infection influence fetal development.The FEBS journal · 2025Review
- Gut microbiota regulates optic nerve fiber myelination.Frontiers in cell and developmental biology · 2025Article
- Fecal Microbiota Transplantation for Attention-Deficit/Hyperactivity Disorder: Mechanisms, Evidence, and Future Directions.International journal of general medicine · 2025Review
- Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats.Metabolic brain disease · 2024Article
- Deciphering the intricate linkage between the gut microbiota and Alzheimer's disease: Elucidating mechanistic pathways promising therapeutic strategies.CNS neuroscience & therapeutics · 2024Review
- Connecting the Dots: The Cerebral Lymphatic System as a Bridge Between the Central Nervous System and Peripheral System in Health and Disease.Aging and disease · 2024Review
- Associations between gut microbiota and adverse neurodevelopmental outcomes in preterm infants: a two-sample Mendelian randomization study.Frontiers in neuroscience · 2024Article
- Targeting Gut Dysbiosis and Microbiome Metabolites for the Development of Therapeutic Modalities for Neurological Disorders.Current neuropharmacology · 2024Article
- Systemic inflammatory proteins in offspring following maternal probiotic supplementation for atopic dermatitis prevention.Clinical and molecular allergy : CMA · 2023Article
- Gut Microbiome-Brain Axis as an Explanation for the Risk of Poor Neurodevelopment Outcome in Preterm Infants with Necrotizing Enterocolitis.Microorganisms · 2023Review
- Neurodevelopmental outcome of infants who develop necrotizing enterocolitis: The gut-brain axis.Seminars in perinatology · 2023Article
- Pathogenesis from the microbial-gut-brain axis in white matter injury in preterm infants: A review.Frontiers in integrative neuroscience · 2023Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neonatal morbidities are associated with long term neurological deficits in life and have also been associated with dysbiosis. We tested whether optimizing the neonate's microbiome through maternal probiotic supplementation can improve offspring's neurodevelopmental outcomes. Maternal LB supplementation, carried out by giving Lactobacillus acidophilus and Bifidobacterium infantis (LB) to pregnant C57/BL6J mice daily from E16 to weaning, significantly suppressed postnatal peripheral proinflammatory insult-induced systemic inflammation and normalized compromised blood-brain barrier permeability and tight junction protein expression in the offspring at pre-weaned age. Maternal LB exposure also regulated markers associated with leukocyte transendothelial migration, extracellular matrix injury and neuroinflammation. The suppressed neuroinflammation by maternal LB supplementation was associated with reduced astrocyte/microglia activation and downregulation of the transcriptional regulators CEBPD and IκBα. Furthermore, maternal LB supplementation promoted neuronal and oligodendrocyte progenitor cell development. Our study demonstrates the efficacy of maternal LB supplementation in modulating systemic and central nervous system inflammation as well as promoting neural/oligodendrocyte progenitor development in the offspring. This evidence suggests that maternal probiotic supplementation may be a safe and effective strategy to improve neurological outcomes in the offspring.
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