Evidence map›Paper›PMID 32424144›Full record

ReviewJournal of human hypertension2020

Blood-brain barrier dysfunction: the undervalued frontier of hypertension.

Vasiliki Katsi, Maria Marketou, Spyridon Maragkoudakis, Matthaios Didagelos, Georgios Charalambous, Fragkiskos Parthenakis, Costas Tsioufis, Dimitrios Tousoulis

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of human hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Impaired Intracranial Compliance: A New Hypertension-Mediated Brain Organ Damage?High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vasiliki Katsi1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece.
Maria MarketouCardiology Department, Heraklion University Hospital, Heraklion, Greece.
Spyridon MaragkoudakisCardiology Department, Heraklion University Hospital, Heraklion, Greece.
Matthaios Didagelos1st Cardiology Department, University General Hospital of Thessaloniki AHEPA, Thessaloniki, Greece. manthosdid@yahoo.gr.ORCID http://orcid.org/0000-0001-8046-0602
Georgios Charalambous1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece.
Fragkiskos ParthenakisCardiology Department, Heraklion University Hospital, Heraklion, Greece.
Costas Tsioufis1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece.
Dimitrios Tousoulis1st Department of Cardiology, Hippokration Hospital, University of Athens Medical School, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The blood-brain barrier (BBB) constitutes the complex anatomic and physiologic interface between the intravascular compartment and the central nervous system, and its integrity is paramount for the maintenance of the very sensitive homeostasis of the central nervous system. Arterial hypertension is a leading cause of morbidity and mortality. The BBB has been shown to be disrupted in essential hypertension. BBB integrity is important for central autonomic control and this may be implicated in the pathophysiology of hypertension. On the other hand, evidence from experimental studies indicates that BBB disruption can be present in both hypertensive disease and dementia syndromes, suggesting a possibly key position of loss of BBB integrity in the pathophysiological pathways linking arterial hypertension with cognitive decline. Although much still remains to be elucidated with respect to the exact underlying mechanisms, the discovery of novel pathological pathways has changed our understanding of adult dementia and central nervous system disease overall, pointing out-in parallel-new potential therapeutic targets. The aim of this review is to summarize current scientific knowledge relevant to the pathophysiologic pathways that are involved in the disruption of the BBB function and potentially mediate hypertension-induced cognitive impairment. In parallel, we underline the differential cognition-preserving effect of several antihypertensive agents of similar blood pressure-lowering capacity, highlighting the presence of previously under-recognized BBB-protective actions of these drugs.

Indexed as

Cognitive DysfunctionHypertensionAdultAntihypertensive AgentsBlood-Brain BarrierCognitionHumansAntihypertensive Agents

Identifiers

PMID32424144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.