Evidence map›Paper›PMID 32424102›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Pleiotropy complicates a trade-off between phage resistance and antibiotic resistance.

Alita R Burmeister, Abigail Fortier, Carli Roush, Adam J Lessing, Rose G Bender, Roxanna Barahman, Raeven Grant, Benjamin K Chan, Paul E Turner

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 184 papers.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed.

  1. Article
  2. High resolution cryo-EM structure of theJournal of structural biology: X · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Enteric populations ofmSphere · 2026
    Article
  13. Article
  14. Giving Antibiotics a Second Chance: Evolutionary Trade-Offs and Phage-Driven Restoration of Antibiotic Susceptibility.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review

124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Alita R BurmeisterDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520; alita.burmeister@yale.edu paul.turner@yale.edu.ORCID 0000-0003-4304-5551
Abigail FortierDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.
Carli RoushDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.ORCID 0000-0002-5992-9944
Adam J LessingDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.
Rose G BenderDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.
Roxanna BarahmanDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.ORCID 0000-0002-6946-2065
Raeven GrantDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.ORCID 0000-0002-9624-4389
Benjamin K ChanDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520.
Paul E TurnerDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520; alita.burmeister@yale.edu paul.turner@yale.edu.ORCID 0000-0003-3490-7498

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Understanding the genetic, evolutionary, and ecological interactions between drug resistance and phage resistanceR21AI144345 · NIAID · YALE UNIVERSITY · PI BURMEISTER, ALITA, TURNER, PAUL E · 2019 to 2020
$441k
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001863NIAID NIH HHS R21 AI144345
6 · The paper itself

Abstract

Bacteria frequently encounter selection by both antibiotics and lytic bacteriophages. However, the evolutionary interactions between antibiotics and phages remain unclear, in particular, whether and when phages can drive evolutionary trade-offs with antibiotic resistance. Here, we describe

Indexed as

Genetic PleiotropyAnti-Bacterial AgentsBacterial Outer Membrane ProteinsColiphagesDrug Resistance, BacterialEscherichia coliEscherichia coli ProteinsGene LibraryGenes, BacterialHost SpecificityLipopolysaccharidesMembrane Transport ProteinsMutationAnti-Bacterial AgentsBacterial Outer Membrane ProteinsEscherichia coli ProteinsLipopolysaccharidesMembrane Transport ProteinstolC protein, E colibacteriophageefflux pumpEscherichia colitrade-offvirus

Identifiers

PMID32424102
PMCPMC7260982

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.