Evidence map›Paper›PMID 32423989›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2020

Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People.

Matthew G McDonald, Lindsay M Henderson, Sutapa Ray, Catherine K Yeung, Amanda L Johnson, John P Kowalski, Helmut Hanenberg, Constanze Wiek, Kenneth E Thummel, Allan E Rettie

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. In Vivo Functional Effects ofDrug metabolism and disposition: the biological fate of chemicals · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Matthew G McDonaldDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Lindsay M HendersonDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Sutapa RayDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Catherine K YeungDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Amanda L JohnsonDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
John P KowalskiDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Helmut HanenbergDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Constanze WiekDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Kenneth E ThummelDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.).
Allan E RettieDepartments of Medicinal Chemistry (M.G.M., S.R., A.L.J., J.P.K., A.E.R.), Pharmaceutics (L.M.H., K.E.T.), and Pharmacy (C.K.Y.), University of Washington, Seattle, Washington; Department of Otorhinolaryngology and Head/Neck Surgery, Heinrich-Heine University, Düsseldorf, Germany (H.H., C.W.); and Department of Pediatrics III, University Children's Hospital Essen, University of Duisburg-Essen, Essen, Germany (H.H.) rettie@uw.edu.
Heinrich Heine University Düsseldorf · DEUniversity of Washington · USUniversity of Duisburg-Essen · DE

Funding

Pharmacological Sciences SupplementT32GM007750 · NIGMS · UNIVERSITY OF WASHINGTON · PI ATKINS, WILLIAM M · 1985 to 2023
$12.6M
Vitamin K gene network: Variant discovery and characterizationP01GM116691 · NIGMS · UNIVERSITY OF WASHINGTON · PI RETTIE, ALLAN EDWARD · 2016 to 2020
$7.6M
NIGMS NIH HHS P01 GM116691NIGMS NIH HHS T32 GM007750
6 · The paper itself

Abstract

CYP2C9 is a major form of human liver cytochrome P450 that is responsible for the oxidative metabolism of several widely used low-therapeutic index drugs, including (

Indexed as

AlaskaCytochrome P-450 CYP2C9Escherichia coliGene ExpressionHEK293 CellsHumansIndigenous PeoplesProteolysisTrypsinCytochrome P-450 CYP2C9Trypsin

Identifiers

PMID32423989
PMCPMC7366286
OpenAlexW3026962315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.