Evidence map›Paper›PMID 32423903›Full record

ArticleClinical medicine (London, England)2020

Thrombotic risk in COVID-19: a case series and case-control study.

Simon M Stoneham, Kate M Milne, Elisabeth Nuttall, Georgina H Frew, Beattie Rh Sturrock, Helena Sivaloganathan, Eleni E Ladikou, Stephen Drage, Barbara Phillips, Timothy Jt Chevassut and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical medicine (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 8 pooled it
2.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 8 syntheses or guidelines pooled it, 80 citations in OpenAlex.

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  5. High rates of pulmonary artery occlusions in COVID-19. A meta-analysis.European journal of clinical investigation · 2021
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  7. A meta-analysis of the incidence of venous thromboembolic events and impact of anticoagulation on mortality in patients with COVID-19.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Simon M StonehamBrighton and Sussex University Hospitals NHS Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK s.stoneham@bsms.ac.uk.
Kate M MilneBrighton and Sussex Medical School, Brighton, UK and Royal Sussex County Hospital, Brighton, UK.
Elisabeth NuttallBrighton and Sussex University Hospitals NHS Trust, Brighton, UK.
Georgina H FrewBrighton and Sussex University Hospitals NHS Trust, Brighton, UK.
Beattie Rh SturrockBrighton and Sussex Medical School, Brighton UK and Royal Sussex County Hospital, Brighton, UK.
Helena SivaloganathanBrighton and Sussex University Hospitals NHS Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK.
Eleni E LadikouBrighton and Sussex University Hospitals NHS Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK.
Stephen DrageBrighton and Sussex University Hospitals NHS Trust, Brighton, UK.
Barbara PhillipsBrighton and Sussex University Hospitals NHS Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK.
Timothy Jt ChevassutBrighton and Sussex Medical School, Brighton UK and consultant haematologist, Royal Sussex County Hospital, Brighton, UK.
Alice C EziefulaBrighton and Sussex University Hospitals NHS Trust, Brighton, UK and Brighton and Sussex Medical School, Falmer, UK.
Brighton and Sussex Medical School · GBUniversity Hospitals Sussex NHS Foundation Trust · GBRoyal Sussex County Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA possible association between COVID-19 infection and thrombosis, either as a direct consequence of the virus or as a complication of inflammation, is emerging in the literature. Data on the incidence of venous thromboembolism (VTE) are extremely limited.

methodsWe describe three cases of thromboembolism refractory to heparin treatment, the incidence of VTE in an inpatient cohort, and a case-control study to identify risk factors associated with VTE.

resultsWe identified 274 confirmed (208) or probable (66) COVID-19 patients. 21 (7.7%) were diagnosed with VTE. D-dimer was elevated in both cases (confirmed VTE) and controls (no confirmed VTE) but higher levels were seen in confirmed VTE cases (4.1 vs 1.2 μg/mL, p<0.001).

conclusionIncidence of VTE is high in patients hospitalised with COVID-19. Urgent clinical trials are needed to evaluate the role of anticoagulation in COVID-19. Monitoring of D-dimer and anti-factor Xa levels may be beneficial in guiding management.

Indexed as

BetacoronavirusAgedAged, 80 and overAnticoagulantsBiomarkersCase-Control StudiesCoronavirus InfectionsCOVID-19FemaleFibrin Fibrinogen Degradation ProductsHeparin, Low-Molecular-WeightHumansIncidenceMaleMiddle AgedPandemicsAnticoagulantsBiomarkersFibrin Fibrinogen Degradation Productsfibrin fragment DHeparin, Low-Molecular-WeightCOVID-19D-dimerdeep vein thrombosispulmonary embolismvenous thromboembolism

Identifiers

PMID32423903
PMCPMC7385762
OpenAlexW3025559985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.