Evidence map›Paper›PMID 32423529›Full record

ArticleeLife2020

CytoCensus, mapping cell identity and division in tissues and organs using machine learning.

Martin Hailstone, Dominic Waithe, Tamsin J Samuels, Lu Yang, Ita Costello, Yoav Arava, Elizabeth Robertson, Richard M Parton, Ilan Davis

Open access · goldAbstract readValidation StudyVideo-Audio Media
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. A Framework for Automated Tracking of Morphologically Distinct Cell Populations in Time-Lapse Microscopy....IEEE...International Conference on Connected Health: Applications, Systems and Engineering Technologies. IEEE International Conference on Connected Health: Applications, Systems and Engineering Technologies · 2026
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  12. Retinal Organoid Technology: Where Are We Now?International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Martin HailstoneDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-9326-3827
Dominic WaitheWolfson Imaging Center & MRC WIMM Centre for Computational Biology MRC Weather all Institute of Molecular Medicine University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-2685-4226
Tamsin J SamuelsDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4670-1139
Lu YangDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Ita CostelloThe Dunn School of Pathology,University of Oxford, Oxford, United Kingdom.
Yoav AravaDepartment of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-2562-9409
Elizabeth RobertsonThe Dunn School of Pathology,University of Oxford, Oxford, United Kingdom.ORCID 0000-0001-6562-0225
Richard M PartonDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-2152-4271
Ilan DavisDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-5385-3053
University of Oxford · GBTechnion – Israel Institute of Technology · IL

Funding

Biotechnology and Biological Sciences Research Council EP/L016052/1Biotechnology and Biological Sciences Research Council MR/K01577X/1Engineering and Physical Sciences Research Council EP/L016052/1Engineering and Physical Sciences Research Council MR/K01577X/1Israel Science Foundation 1096/13Medical Research Council EP/L016052/1Medical Research Council G0902418Medical Research Council MC_UU_12009Medical Research Council MC_UU_12010Medical Research Council MC_UU_12025Medical Research Council MR/K01577X/1Medical Research Council MR/S005382/1Medical Research Council MR/S005382/1aOxford University Press Clarendon FellowshipWellcome 091911/B/10/ZWellcome 096144/Z/17/ZWellcome 105363/Z/14/ZWellcome 107457/Z/15/ZWellcome 209412/Z/17/ZWellcome 214175/Z/18/ZWellcome Trust 081858Wellcome Trust 209412/Z/17/Z
6 · The paper itself

Abstract

A major challenge in cell and developmental biology is the automated identification and quantitation of cells in complex multilayered tissues. We developed CytoCensus: an easily deployed implementation of supervised machine learning that extends convenient 2D 'point-and-click' user training to 3D detection of cells in challenging datasets with ill-defined cell boundaries. In tests on such datasets, CytoCensus outperforms other freely available image analysis software in accuracy and speed of cell detection. We used CytoCensus to count stem cells and their progeny, and to quantify individual cell divisions from time-lapse movies of explanted

Indexed as

Cell DivisionImage Processing, Computer-AssistedMachine LearningMicroscopy, VideoTime-Lapse ImagingAnimalsAnimals, Genetically ModifiedAutomationBrainDrosophila melanogasterEmbryo, MammalianFemaleLarvaMaleMiceMutation3D cell detection4D image analysiscell biologydevelopmental biologyD. melanogasterex vivo culturelive imagingmouseneural stem cellszebrafish

Identifiers

PMID32423529
PMCPMC7237217
OpenAlexW3027927758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.