Evidence map›Paper›PMID 32423528›Full record

ArticleeLife2020

Combining magnetoencephalography with magnetic resonance imaging enhances learning of surrogate-biomarkers.

Denis A Engemann, Oleh Kozynets, David Sabbagh, Guillaume Lemaître, Gael Varoquaux, Franziskus Liem, Alexandre Gramfort

Abstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Tracking electrophysiological signatures of Alzheimer's disease: a systematic review of multimodal studies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Pooled it
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  14. Temporal autocorrelation is predictive of age-An extensive MEG time-series analysis.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Denis A EngemannUniversité Paris-Saclay, Inria, CEA, Palaiseau, France.ORCID 0000-0002-7223-1014
Oleh KozynetsUniversité Paris-Saclay, Inria, CEA, Palaiseau, France.
David SabbaghUniversité Paris-Saclay, Inria, CEA, Palaiseau, France.
Guillaume LemaîtreUniversité Paris-Saclay, Inria, CEA, Palaiseau, France.
Gael VaroquauxUniversité Paris-Saclay, Inria, CEA, Palaiseau, France.ORCID 0000-0003-1076-5122
Franziskus LiemUniversity Research Priority Program Dynamics of Healthy Aging, University of Zürich, Zürich, Switzerland.
Alexandre GramfortUniversité Paris-Saclay, Inria, CEA, Palaiseau, France.

Funding

H2020 European Research Council SLAB ERC-StG-676943Inria Médecine Numérique 2018Inserm Médecine Numérique 2018
6 · The paper itself

Abstract

Electrophysiological methods, that is M/EEG, provide unique views into brain health. Yet, when building predictive models from brain data, it is often unclear how electrophysiology should be combined with other neuroimaging methods. Information can be redundant, useful common representations of multimodal data may not be obvious and multimodal data collection can be medically contraindicated, which reduces applicability. Here, we propose a multimodal model to robustly combine MEG, MRI and fMRI for prediction. We focus on age prediction as a surrogate biomarker in 674 subjects from the Cam-CAN dataset. Strikingly, MEG, fMRI and MRI showed additive effects supporting distinct brain-behavior associations. Moreover, the contribution of MEG was best explained by cortical power spectra between 8 and 30 Hz. Finally, we demonstrate that the model preserves benefits of stacking when some data is missing. The proposed framework, hence, enables multimodal learning for a wide range of biomarkers from diverse types of brain signals.

Indexed as

AlgorithmsBrain WavesCognitionCognitive AgingFunctional NeuroimagingMagnetic Resonance ImagingMagnetoencephalographyAdolescentAdultAgedAged, 80 and overAge FactorsBrainFemaleHumansMaleagingbiomarkerhumanhuman biologymachine learningmagnetic resonance imagingmagnetoencephalogrphymedicineneuroscienceoscillations

Identifiers

PMID32423528
PMCPMC7308092

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.