ArticleArthritis research & therapy2020
Sex hormone-binding globulin and arthritis: a Mendelian randomization study.
Article in Arthritis research & therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 4 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 4 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- The mediating effects of plasma proteome on the association between selenium and systemic lupus erythematosus.Clinical rheumatology · 2026Pooled it
- Causal risk and protective factors for rheumatoid arthritis: a comprehensive mendelian randomization systematic review and meta-analysis.Frontiers in genetics · 2026Pooled it
- Using Mendelian randomization analyses in osteoarthritis: state of art and future perspectives.Annals of medicine · 2025Pooled it
- Mendelian Randomization Studies of Lifestyle-Related Risk Factors for Osteoarthritis: A PRISMA Review and Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- Association between sex-hormone binding globulin and cardiovascular events in patients with rheumatoid arthritis.Clinical rheumatology · 2026Article
- Integration of clinical features and metabolomics study reveals sex dimorphism in knee osteoarthritis.BMC musculoskeletal disorders · 2026Article
- Multisite Chronic Pain Reveals Neuro-Immune-Metabolic Dysregulation across Rheumatoid Arthritis and Depression.Research (Washington, D.C.) · 2026Article
- The causal effects of genetically predicted sex hormone-binding globulin and sarcopenia: A 2-sample Mendelian randomization study.Medicine · 2025Article
- Mendelian randomization study reveals the causal effect of sex hormone binding globulin on osteoporosis.BMC musculoskeletal disorders · 2025Article
- Investigating the Mediating Role of Cardiometabolic Traits in the Causal Link Between SHBG Levels and Stroke Risk via Network Mendelian Randomization.Current issues in molecular biology · 2025Article
- Associations between measures of oestrogen exposure and severity of Fuchs endothelial corneal dystrophy.BMJ open ophthalmology · 2025Article
- Associations between endogenous sex hormones and multisite chronic musculoskeletal pain.British journal of anaesthesia · 2025Article
- The causal effect of matrix metalloproteinase-3 on ankylosing spondylitis: Evidence from Mendelian randomization.Medicine · 2025Article
- Application of Elastic networks and Bayesian networks to explore influencing factors associated with arthritis in middle-aged and older adults in the Chinese community.Frontiers in public health · 2025Article
- Causal factors for osteoarthritis risk revealed by mendelian randomization analysis.Aging clinical and experimental research · 2024Review
- Exploring the causal association between frailty index with the common types of arthritis: a Mendelian randomization analysis.Aging clinical and experimental research · 2024Article
- Is chronic kidney disease associated with osteoarthritis? The United States national health and nutrition examination survey 2011-2020.BMC nephrology · 2024Article
- The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization.Calcified tissue international · 2024Article
- Causal Factors for Osteoarthritis: A Scoping Review of Mendelian Randomization Studies.Arthritis care & research · 2024Article
- Sex hormone imbalance and rheumatoid arthritis in American men: a cross-sectional analysis from NHANES 2011-2016.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSex hormone-binding globulin (SHBG) has been reported to be a risk factor associated with the development of arthritis by previous observational studies more so of three common forms of arthritis: osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). This study aimed to determine whether the concentrations of circulating SHBG are causally associated with the risk of OA, RA, and AS.
methodsThe two-sample Mendelian randomization (MR) approach was used for this study. The inverse-variance-weighted (IVW) method was used for the main analysis. Single-nucleotide polymorphisms (SNPs) associated with SHBG were selected from a large genome-wide association study (GWAS) of 28,837 European individuals. The summary statistics for OA, RA, and AS were extracted from the UK Biobank Resource (n = 361,141) and a GWAS dataset (n = 455,221).
resultsPositive causal associations were found between circulating SHBG concentrations and OA (effect = 1.086; 95% CI, 1.009 to 1.168; P = 0.027) and RA (effect = 1.003; 95% CI, 1.000 to 1.007; P = 0.047) in overall analyses. However, there was no evidence of association between SHBG levels and AS. Based on the stratification of skeletal sites, SHBG levels were found to be significantly associated with hip OA (effect = 1.423; 95% CI, 1.219 to 1.660; P = 7.753 × 10
conclusionsThere were positive causal effects of circulating SHBG on the development of OA and RA. Moreover, there was a site-specific association between SHBG and hip OA. Evidently, measurement of SHBG in serum could be valuable in the clinical assessment of arthritis especially in early screening and prevention of OA and RA. However, the mechanisms by which SHBG plays causal roles in the development of arthritis require further investigations.
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