Evidence map›Paper›PMID 32423392›Full record

ArticleBMC pediatrics2020

Effect of feeding mode on infant growth and cognitive function: study protocol of the Chilean infant Nutrition randomized controlled Trial (ChiNuT).

Rosario Toro-Campos, Cecilia Algarín, Patricio Peirano, Marcela Peña, Teresa Murguia-Peniche, Steven S Wu, Ricardo Uauy

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02626143 (Effect of Feeding Mode on Infant Growth and Cognitive Function), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02626143 nacompletednot on this map

Effect of Feeding Mode on Infant Growth and Cognitive Function

TypeinterventionalSponsorMead Johnson NutritionRan2016 to 2019Enrolled582ConditionsInfant NutritionArmsInvestigational nutrient-rich whey protein formula, Cow's milk based formula
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rosario Toro-CamposInstitute of Nutrition and Food Technology (INTA), University of Chile, Av El Libano 5524, Macul, Santiago, Chile. rosario.toro@inta.uchile.cl.
Cecilia AlgarínInstitute of Nutrition and Food Technology (INTA), University of Chile, Av El Libano 5524, Macul, Santiago, Chile.
Patricio PeiranoInstitute of Nutrition and Food Technology (INTA), University of Chile, Av El Libano 5524, Macul, Santiago, Chile.
Marcela PeñaPsychology Department, Pontific Catholic University, Santiago, Chile.
Teresa Murguia-PenicheMedical Affairs, Mead Johnson Nutrition, Evansville, IN, USA.
Steven S WuMedical Affairs, Mead Johnson Nutrition, Evansville, IN, USA.
Ricardo UauyInstitute of Nutrition and Food Technology (INTA), University of Chile, Av El Libano 5524, Macul, Santiago, Chile.
University of Chile · CLMead Johnson (United States) · USPontificia Universidad Católica de Chile · CL

Funding

Mead Johnson Nutrition 6092
6 · The paper itself

Abstract

backgroundA central aim for pediatric nutrition is to develop infant formula compositionally closer to human milk. Milk fat globule membranes (MFGM) have shown to have functional components that are found in human milk, suggesting that addition of bovine sources of MFGM (bMFGM) to infant formula may promote beneficial outcomes potentially helping to narrow the gap between infants who receive human breast milk or infant formula. The objective of the current study is to determine how the addition of bMFGM in infant formula and consumption in early infancy affects physical growth and brain development when compared to infants fed with a standard formula and a reference group of infants fed with mother's own milk.

methodsSingle center, double-blind, and parallel randomized controlled trial. Planned participant enrollment includes: infants exclusively receiving breast milk (n = 200; human milk reference group; HM) and infants whose mothers chose to initiate exclusive infant formula feeding before 4 months of age (n = 340). The latter were randomized to receive one of two study formulas until 12 months of age: 1) cow's milk based infant formula that had docosahexaenoic (DHA) (17 mg/100 kcal) and arachidonic acid (ARA) (25 mg/100 kcal); 1.9 g protein/100 kcal; 1.2 mg Fe/100 kcal (Standard formula; SF) or 2) a similar infant formula with an added source of bovine MFGM (whey protein-lipid concentrate (Experimental formula; EF). Primary outcomes will be: 1) Physical growth (Body weight, length, and head circumference) at 730 days of age; and 2) Cognitive development (Auditory Event-Related Potential) at 730 days of age. Data will be analyzed for all participants allocated to each study feeding group. DISCUSSION: The results of this study will complement the knowledge regarding addition of bMFGM in infant formula including support of healthy growth and improvement of neurodevelopmental outcomes.

trial registrationNCT02626143, registered on December 10th 2015.

Indexed as

Infant FormulaInfant Nutritional Physiological PhenomenaAnimalsBreast FeedingCattleChildChild, PreschoolChileCognitionFemaleHumansInfantMilk, HumanRandomized Controlled Trials as TopicBreast feedingChileClinical trialsInfant formulaMilk fat globule membrane, MFGM, growth and development

Identifiers

PMID32423392
PMCPMC7236373
OpenAlexW3026582046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.