Evidence map›Paper›PMID 32423348›Full record

Observational studyAnnals of internal medicine2020

Associations Between Dietary Patterns and Subclinical Cardiac Injury: An Observational Analysis From the DASH Trial.

Stephen P Juraschek, Lara C Kovell, Lawrence J Appel, Edgar R Miller, Frank M Sacks, Robert H Christenson, Heather Rebuck, Alexander R Chang, Kenneth J Mukamal

Registry-linked trialOpen access · greenAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Annals of internal medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000544 (Dietary Approaches to Stop Hypertension), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000544 phase3completednot on this map

Dietary Approaches to Stop Hypertension (DASH)

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran1993 to 1997ConditionsCardiovascular Diseases, Heart Diseases, Hypertension, Vascular DiseasesArmsdiet therapy
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

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  3. Associations of Hypertension and Orthostatic Hypotension With Subclinical Cardiovascular Disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Stephen P JuraschekBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (S.P.J., K.J.M.).
Lara C KovellUniversity of Massachusetts Medical School, Worcester, Massachusetts (L.C.K.).
Lawrence J AppelThe Johns Hopkins University School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland (L.J.A., E.R.M.).
Edgar R MillerThe Johns Hopkins University School of Medicine, The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, Maryland (L.J.A., E.R.M.).
Frank M SacksHarvard T.H. Chan School of Public Health, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts (F.M.S.).
Robert H ChristensonUniversity of Maryland School of Medicine, Baltimore, Maryland (R.H.C., H.R.).
Heather RebuckUniversity of Maryland School of Medicine, Baltimore, Maryland (R.H.C., H.R.).
Alexander R ChangGeisinger Health System, Danville, Pennsylvania (A.R.C.).
Kenneth J MukamalBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (S.P.J., K.J.M.).
Beth Israel Deaconess Medical Center · USJohns Hopkins University · USUniversity of Maryland, Baltimore · USBrigham and Women's Hospital · USGeisinger Health System · USUniversity of Massachusetts Chan Medical School · US

Funding

Zoledronic Acid in Treatment of Osteoporosis in PostmenoM01RR002635 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI CZEISLER, CHARLES A · 1985 to 2008
$48.4M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D · 2005 to 2019
$17.3M
Vitamin D, Subclinical Cardiovascular Disease, and Orthostatic Hypotension in Older AdultsK23HL135273 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2017 to 2021
$1.1M
The Effects of the DASH Diet and Sodium Reduction on Subclinical Cardiac DamageR21HL144876 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI JURASCHEK, STEPHEN P · 2018 to 2019
$263k
ZIDOVUDINE WITH PROBENECID--EFFECTS OF PROBENECID ON ZIDOVUDINEM01RR000722 · NCRR · JOHNS HOPKINS UNIVERSITY · PI MILLER, EDWARD D · 1985 to 1996
–
NCRR NIH HHS M01 RR000722NCRR NIH HHS M01 RR002635NHLBI NIH HHS K23 HL135273NHLBI NIH HHS R21 HL144876NIDDK NIH HHS P30 DK072488
6 · The paper itself

Abstract

backgroundThe DASH diet has been found to lower blood pressure (BP) and low-density lipoprotein cholesterol levels.

objectiveTo compare diets rich in fruits and vegetables with a typical American diet in their effects on cardiovascular injury in middle-aged adults without known preexisting cardiovascular disease (CVD).

designObservational study based on a 3-group, parallel-design, randomized trial conducted in the United States from 1994 to 1996. (ClinicalTrials.gov: NCT00000544).

setting3 of the 4 original clinical trial centers.

participants326 of the original 459 trial participants with available stored specimens.

interventionParticipants were randomly assigned to 8 weeks of monitored feeding with a control diet typical of what many Americans eat; a diet rich in fruits and vegetables but otherwise similar to the control diet; or the DASH diet, which is rich in fruits, vegetables, low-fat dairy, and fiber and has low levels of saturated fat and cholesterol. Weight was kept constant throughout feeding. MEASUREMENTS: Biomarkers collected at baseline and 8 weeks: high-sensitivity cardiac troponin I (hs-cTnI),

resultsThe mean age of participants was 45.2 years, 48% were women, 49% were black, and mean baseline BP was 131/85 mm Hg. Compared with the control diet, the fruit-and-vegetable diet reduced hs-cTnI levels by 0.5 ng/L (95% CI, -0.9 to -0.2 ng/L) and NT-proBNP levels by 0.3 pg/mL (CI, -0.5 to -0.1 pg/mL). Compared with the control diet, the DASH diet reduced hs-cTnI levels by 0.5 ng/L (CI, -0.9 to -0.1 ng/L) and NT-proBNP levels by 0.3 pg/mL (CI, -0.5 to -0.04 pg/mL). Levels of hs-CRP did not differ among diets. None of the markers differed between the fruit-and-vegetable and DASH diets. LIMITATION: Short duration, missing specimens, and an inability to isolate the effects of specific foods or micronutrients.

conclusionDiets rich in fruits and vegetables given over 8 weeks were associated with lower levels of markers for subclinical cardiac damage and strain in adults without preexisting CVD. PRIMARY FUNDING SOURCE: National Institutes of Health, National Heart, Lung, and Blood Institute.

Indexed as

AdultBiomarkersBlood PressureCardiovascular DiseasesC-Reactive ProteinDiet, Fat-RestrictedFemaleHumansMaleMiddle AgedNatriuretic Peptide, BrainPeptide FragmentsProtein PrecursorsRetrospective StudiesBiomarkersC-Reactive ProteinNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Protein PrecursorsAttentionCardiovascular diseasesDietFatsFoodHypercholesterolemiaLongitudinal studiesObservational studiesSensitivityTroponin

Identifiers

PMID32423348
PMCPMC7388686
OpenAlexW3024197983

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.