Trial reportJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2020
Collateral status contributes to differences between observed and predicted 24-h infarct volumes in DEFUSE 3.
Trial report in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Chinese Stroke Association guidelines for clinical management of ischaemic cerebrovascular diseases: executive summary and 2023 update.Stroke and vascular neurology · 2023Guideline
- MRI for collateral assessment pre-thrombectomy and association with outcome: a systematic review and meta-analysis.Neuroradiology · 2023Pooled it
- Aspiration versus stent retriever for posterior circulation stroke: A meta-analysis.CNS neuroscience & therapeutics · 2023Pooled it
- Collateral Circulation andJournal of the American Heart Association · 2025Trial
- High-definition Cathodal Direct Current Stimulation for Treatment of Acute Ischemic Stroke: A Randomized Clinical Trial.JAMA network open · 2023Trial
- Predicting severe disability or death in endovascular thrombectomy with large computed tomography perfusion core infarction and limited penumbra.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026Article
- Unfavorable Perfusion Collateral Impairment Score Is Associated with Higher Odds of Poor Outcomes in Large Vessel Occlusion Stroke.Stroke (Hoboken, N.J.) · 2025Article
- The Role of CT Perfusion in the Evaluation and Management of Acute Ischemic Stroke-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Association of Computed Tomography Perfusion Parameters with 90-Day Functional Independence After Endovascular Thrombectomy.Journal of clinical medicine · 2025Article
- Integrating perfusion imaging derived venous outflow and tissue-level collateral parameters in a comprehensive clinical model enhances prognostication in large vessel occlusion stroke.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Real-world functional outcomes and predictors of futile recanalization in patients meeting criteria for SELECT2.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Role of Hypoperfusion Intensity Ratio in Vessel Occlusions: A Review on Safety and Clinical Outcomes.AJNR. American journal of neuroradiology · 2025Review
- Time-variant and tissue-level collaterals predict postoperative neurological recovery and clinical outcomes of patients with endovascular thrombectomy.Quantitative imaging in medicine and surgery · 2025Article
- Long-term functional outcomes for elderly patients treated with endovascular thrombectomy.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Prolonged Venous Transit as a Superior Predictor of Functional Outcomes in Successfully Reperfused Large Vessel Occlusions: Comparative Analysis With Cerebral Blood Volume Index and Hypoperfusion Intensity Ratio.Journal of the American Heart Association · 2025Article
- Validation of the Charlotte large artery occlusion endovascular therapy outcome score using Viz.ai-derived cerebral blood volume index.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Association between Cerebral Blood Volume Index and Excellent Reperfusion in Acute Ischemic Stroke Patients Undergoing Mechanical Thrombectomy.Current neurovascular research · 2025Article
- Perfusion-Based Relative Cerebral Blood Volume Is Associated With Functional Dependence in Large-Vessel Occlusion Ischemic Stroke.Journal of the American Heart Association · 2024Article
- CT perfusion derived relative cerebral blood volume < 42 % is negatively associated with poor functional outcomes at discharge in anterior circulation large vessel occlusion stroke.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2024Article
- Cerebral collaterals are associated with pre-treatment brain-blood barrier permeability in acute ischemic stroke patients.European radiology · 2024Observational
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We previously demonstrated that in the DEFUSE 3 trial, the union of the baseline core and the 24-h Tmax > 6 s perfusion lesion predicts the infarct volume at 24 h. Presently, we assessed if collateral robustness measured by the hypoperfusion intensity ratio (HIR) and cerebral blood volume (CBV) index accounts for the variance in these predictions. DEFUSE 3 patients underwent MRI/CT perfusion imaging at baseline and 24 h post-randomization. We compared baseline and follow-up HIR and CBV index across subgroups stratified by differences between predicted and observed 24-h infarct volumes. Of 123 eligible patients, 34 with 24-h infarcts larger than predicted had less favorable collaterals at baseline (HIR 0.43 vs. 0.32,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.