Evidence map›Paper›PMID 32423268›Full record

ReviewPlatelets2020

Use of electron microscopy to study platelets and thrombi.

Maurizio Tomaiuolo, Rustem I Litvinov, John W Weisel, Timothy J Stalker

Abstract readReview
In one paragraph

Review in Platelets, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Review
  2. Article
  3. Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Rupture mechanics of blood clot fibrin fibers: A coarse-grained model study.Journal of the mechanics and physics of solids · 2025
    Article
  8. Thrombocytopenia in Sepsis.Life (Basel, Switzerland) · 2025
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maurizio TomaiuoloDepartment of Medicine and Perelman School of Medicine, University of Pennsylvania , Philadelphia, USA.
Rustem I LitvinovDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, USA.
John W WeiselDepartment of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, USA.
Timothy J StalkerDepartment of Medicine and Perelman School of Medicine, University of Pennsylvania , Philadelphia, USA.ORCID https://orcid.org/0000-0002-0017-4268

Funding

Translating Mechanistic Insights into Intrinsic Xase FunctionP01HL139420 · NHLBI · CHILDREN'S HOSP OF PHILADELPHIA · PI Sriram Krishnaswamy · 2018 to 2026
$22.4M
Thrombosis Models CoreP01HL120846 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ABRAMS, CHARLES S. · 2014 to 2018
$12.2M
Experiment-based multi-scale modeling of the tensile and compressive deformations of fibrinR01HL135254 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PUROHIT, PRASHANT KISHORE · 2017 to 2020
$1.6M
NHLBI NIH HHS P01 HL120846NHLBI NIH HHS P01 HL139420NHLBI NIH HHS R01 HL135254
6 · The paper itself

Abstract

Electron microscopy has been a valuable tool for the study of platelet biology and thrombosis for more than 70 years. Early studies using conventional transmission and scanning electron microscopy (EM) provided a foundation for our initial understanding of platelet structure and how it changes upon platelet activation. EM approaches have since been utilized to study platelets and thrombi in the context of basic, translational and clinical research, and they are instrumental in the diagnosis of multiple platelet function disorders. In this brief review, we provide a sampling of the many contributions EM based studies have made to the field, including both historical highlights and contemporary applications. We will also discuss exciting new imaging modalities based on EM and their utility for the study of platelets, hemostasis and thrombosis into the future.

Indexed as

Blood PlateletsHemostasisHumansMicroscopy, ElectronThrombosisHemostasisplateletscanning electron microscopythrombosistransmission electron microscopy

Identifiers

PMID32423268
PMCPMC7332414

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.