ArticleJournal of clinical medicine2020
Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sjögren's Syndrome.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Idiopathic inflammatory myopathy associated with Sjögren's disease: features of a distinct clinical entity.Frontiers in immunology · 2025Article
- Neurological and Psychiatric Clinical Manifestations of Sjögren Syndrome.Current neurology and neuroscience reports · 2024Review
- Optical coherence tomography angiography suggests different retinal pathologies in multiple sclerosis and Sjögren's syndrome.Journal of neurology · 2024Article
- The Spectrum of Extraglandular Manifestations in Primary Sjögren's Syndrome.Journal of personalized medicine · 2023Review
- Sjögren's syndrome with and without neurological involvement.Journal of neurology · 2023Article
- Infiltrating circulating monocytes provide an important source of BMP4 at the early stage of spinal cord injury.Disease models & mechanisms · 2023Article
- CNS demyelinating events in primary Sjögren's syndrome: A single-center case series on the clinical phenotype.Frontiers in neurology · 2023Article
- Central Nervous System Involvement in Primary Sjögren's Syndrome: Narrative Review of MRI Findings.Diagnostics (Basel, Switzerland) · 2022Review
- The utility of diffusion-weighted imaging in patients with spinal cord infarction: difference from the findings of neuromyelitis optica spectrum disorder.BMC neurology · 2022Article
- Saliva Free Light Chains in Patients with Neuro-Sjögren.Biomedicines · 2022Article
- Trigeminal Nerve Affection in Patients with Neuro-Sjögren Detected by Corneal Confocal Microscopy.Journal of clinical medicine · 2022Article
- Neuroimaging Pearls from the MDS Congress Video Challenge. Part 2: Acquired Disorders.Movement disorders clinical practice · 2022Review
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify radiological and laboratory hallmarks in patients with primary Sjögren's syndrome (pSS) presenting with spinal cord involvement.
methodsClinical and laboratory routine parameters were analyzed in a retrospective multicenter case series of four patients who developed myelitis associated with pSS. Serological and cerebrospinal fluid (CSF) measurements of pSS associated anti-SSA(Ro)-antibodies were initiated, and CSF neurofilament light chain (NFL) levels were assessed. NFL values were compared with results from 15 sex- and age-matched healthy controls. Radiological assessment was performed using multi-sequence spinal cord magnetic resonance imaging.
resultsThree of the four patients initially developed neurological signs suggestive of myelitis and were subsequently diagnosed with pSS. All patients presented a longitudinal spinal T2-hyperintense lesion in the cervical spinal cord, whereas only two patients showed pleocytosis and oligoclonal bands in the CSF. Median (range) CSF-NFL levels were significantly elevated in patients compared to controls (6672 pg/mL (621-50000) vs. 585 pg/mL (357-729),
conclusionInflammatory spinal cord lesions associated with pSS are a rare but serious disease leading to severe disability. NFL and anti-SSA(Ro)-antibodies in CSF might serve as prognostic biomarkers and should be routinely assessed in patients with pSS.
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