Evidence map›Paper›PMID 32423045›Full record

ArticleInternational journal of molecular sciences2020

Dynamic Changes of Heart Failure Biomarkers in Response to Parabolic Flight.

Peter Jirak, Bernhard Wernly, Michael Lichtenauer, Vera Paar, Marcus Franz, Thorben Knost, Thaer Abusamrah, Malte Kelm, Johanna M Muessig, Nana-Yaw Bimpong-Buta and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Microgravity and Space Medicine.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Peter JirakDepartment of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.
Bernhard WernlyDepartment of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.ORCID 0000-0003-4024-0220
Michael LichtenauerDepartment of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.ORCID 0000-0003-0755-7955
Vera PaarDepartment of Internal Medicine II, Division of Cardiology, Paracelsus Medical University of Salzburg, 5020 Salzburg, Austria.
Marcus FranzDepartment of Internal Medicine I, Jena University Hospital, Friedrich Schiller University Jena, 07743 Jena, Germany.ORCID 0000-0001-6543-4684
Thorben KnostDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.
Thaer AbusamrahDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.
Malte KelmDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.
Johanna M MuessigDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.ORCID 0000-0003-2521-5609
Nana-Yaw Bimpong-ButaDivision of Cardiology and Rhythmology, Evangelical Hospital Hagen-Haspe, 58135 Hagen, Germany.
Christian JungDivision of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, 40225 Duesseldorf, Germany.
Heinrich Heine University Düsseldorf · DEUniversity of Salzburg · ATJena University Hospital · DE

Funding

Deutsches Zentrum für Luft- und Raumfahrt 50WB1714
6 · The paper itself

Abstract

backgroundwe aimed at investigating the influence of weightlessness and hypergravity by means of parabolic flight on the levels of the heart failure biomarkers H-FABP, sST2, IL-33, GDF-15, suPAR and Fetuin-A.

methods14 healthy volunteers (males: eight; mean age: 28.9) undergoing 31 short-term phases of weightlessness and hypergravity were included. At different time points (baseline, 1 h/24 h after parabolic flight), venous blood was drawn and analyzed by the use of ELISA.

resultssST2 evidenced a significant decrease 24 h after parabolic flight (baseline vs. 24,

conclusionOur results suggest a reduction in cardiac stress induced by exposure to gravitational changes. Moreover, our findings indicate an influence of gravitational changes on proliferative processes and calcium homeostasis.

Indexed as

Adultalpha-2-HS-GlycoproteinBiomarkersCalciumFatty Acid Binding Protein 3FemaleGrowth Differentiation Factor 15Heart FailureHumansHypergravityInterleukin-33MaleSpace FlightWeightlessnessAHSG protein, humanalpha-2-HS-GlycoproteinBiomarkersCalciumFABP3 protein, humanFatty Acid Binding Protein 3GDF15 protein, humanGrowth Differentiation Factor 15Interleukin-33biomarkersheart failuremicrogravityparabolic flightspace medicineweightlessness

Identifiers

PMID32423045
PMCPMC7279017
OpenAlexW3024205996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.