Evidence map›Paper›PMID 32422990›Full record

ArticleToxins2020

An Integrated Proteomic and Transcriptomic Analysis Reveals the Venom Complexity of the Bullet Ant

Samira R Aili, Axel Touchard, Regan Hayward, Samuel D Robinson, Sandy S Pineda, Hadrien Lalagüe, Mrinalini, Irina Vetter, Eivind A B Undheim, R Manjunatha Kini and 4 more

Open access · goldAbstract read
In one paragraph

Article in Toxins, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Toxins · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Overview of protein posttranslational modifications in Arthropoda venoms.The journal of venomous animals and toxins including tropical diseases · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Samira R AiliSchool of Life Sciences, University of Technology Sydney, Broadway, NSW 2007, Australia.ORCID 0000-0002-2933-0527
Axel TouchardCNRS, UMR Ecologie des Forêts de Guyane, AgroParisTech, CIRAD, INRA, Université de Guyane, Université des Antilles, Campus Agronomique, BP316, CEDEX, 97379 Kourou, France.
Regan HaywardSchool of Life Sciences, University of Technology Sydney, Broadway, NSW 2007, Australia.
Samuel D RobinsonInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.ORCID 0000-0002-3518-0377
Sandy S PinedaBrain and Mind Centre, University of Sydney, Camperdown, Sydney, NSW 2050, Australia.
Hadrien LalagüeCNRS, UMR Ecologie des Forêts de Guyane, AgroParisTech, CIRAD, INRA, Université de Guyane, Université des Antilles, Campus Agronomique, BP316, CEDEX, 97379 Kourou, France.
MrinaliniProtein Science Laboratory, Department of Biological Science, Faculty of Science, National University of Singapore, Singapore 117543, Singapore.
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD 4072, Australia.
Eivind A B UndheimCentre for Advanced Imaging, The University of Queensland, St. Lucia, QLD 4072, Australia.
R Manjunatha KiniProtein Science Laboratory, Department of Biological Science, Faculty of Science, National University of Singapore, Singapore 117543, Singapore.ORCID 0000-0002-6100-3251
Pierre EscoubasFaculty of Science, University of Nice, 06000 Nice, France.
Matthew P PadulaSchool of Life Sciences, University of Technology Sydney, Broadway, NSW 2007, Australia.ORCID 0000-0002-8283-0643
Garry S A MyersSchool of Life Sciences, University of Technology Sydney, Broadway, NSW 2007, Australia.
Graham M NicholsonSchool of Life Sciences, University of Technology Sydney, Broadway, NSW 2007, Australia.ORCID 0000-0002-4277-4296
University of Technology Sydney · AUThe University of Queensland · AUCentre National de la Recherche Scientifique · FRNational University of Singapore · SGThe University of Sydney · AUUniversité Côte d'Azur · FR

Funding

Australian Research Council DE160101142Australian Research Council DP160104025"Investissement d'Avenir" grant from the Agence Nationale de la Recherche CEBA, ANR-10-LABX-25-01; project EVANorwegian Research Council FRIPRO-YRT Fellowship no. 287462PO-FEDER 2014-2020, Région Guyane BING (GY0007194)PO-FEDER 2014-2020, Région Guyane FORMIC (GY0013708)Southeast Asian Biodiversity Genomics Center, National University of Singapore R-154-000-648-646
6 · The paper itself

Abstract

A critical hurdle in ant venom proteomic investigations is the lack of databases to comprehensively and specifically identify the sequence and function of venom proteins and peptides. To resolve this, we used venom gland transcriptomics to generate a sequence database that was used to assign the tandem mass spectrometry (MS) fragmentation spectra of venom peptides and proteins to specific transcripts. This was performed alongside a shotgun liquid chromatography-mass spectrometry (LC-MS/MS) analysis of the venom to confirm that these assigned transcripts were expressed as proteins. Through the combined transcriptomic and proteomic investigation of

Indexed as

Gene Expression ProfilingProteomeProteomicsTranscriptomeAnimalsAntsAnt VenomsCalciumCells, CulturedChromatography, High Pressure LiquidChromatography, Reverse-PhaseDatabases, GeneticGanglia, SpinalInsect ProteinsMice, Inbred C57BLNeurotoxinsAnt VenomsCalciumInsect ProteinsNeurotoxinsProteomeDRG neuronshyaluronidaseneurotoxinsparaponeritoxinphospholipasesRP-HPLC

Identifiers

PMID32422990
PMCPMC7290781
OpenAlexW3025482717

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.