Evidence map›Paper›PMID 32422879›Full record

ArticleInternational journal of molecular sciences2020

Corin Overexpression Reduces Myocardial Infarct Size and Modulates Cardiomyocyte Apoptotic Cell Death.

Ryan D Sullivan, Aiilyan K Houng, Inna P Gladysheva, Tai-Hwang M Fan, Ranjana Tripathi, Guy L Reed, Dong Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  13. Single-Nucleotide Polymorphisms in the 3' Untranslated Region ofFrontiers in cardiovascular medicine · 2021
    Article
  14. Proteomic Profiling Reveals Roles of Stress Response, CaAlcoholism, clinical and experimental research · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ryan D SullivanDepartment of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Aiilyan K HoungDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Inna P GladyshevaDepartment of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.ORCID 0000-0002-2501-9029
Tai-Hwang M FanDepartment of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Ranjana TripathiDepartment of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Guy L ReedDepartment of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
Dong WangDepartment of Internal Medicine, University of Arizona College of Medicine-Phoenix, Phoenix, AZ 85004, USA.
University of Arizona · USUniversity of Tennessee Health Science Center · US

Funding

Corin in Cardiomyopathy and Heart FailureR01HL115036 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GLADYSHEVA, INNA P · 2012 to 2016
$2.4M
Alpha-2-antiplasmin and Ischemic StrokeR01NS089707 · NINDS · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI REED, GUY L · 2015 to 2019
$1.9M
Novel Methods for Dissolving Blood ClotsR41HL092750 · NHLBI · TRANSLATIONAL SCIENCES, INC. · PI REED, GUY L · 2010 to 2010
$168k
American Heart Association 0835376NAmerican Heart Association 14SDG20510068NHLBI NIH HHS R01 HL115036NHLBI NIH HHS R41 HL092750NIH HHS HL092750NIH HHS HL115036NIH HHS NS089707NINDS NIH HHS R01 NS089707Valley Research Partnership Award VRP46
6 · The paper itself

Abstract

Altered expression of corin, a cardiac transmembrane serine protease, has been linked to dilated and ischemic cardiomyopathy. However, the potential role of corin in myocardial infarction (MI) is lacking. This study examined the outcomes of MI in wild-type vs. cardiac-specific overexpressed corin transgenic (Corin-Tg) mice during pre-MI, early phase (3, 24, 72 h), and late phase (1, 4 weeks) post-MI. Corin overexpression significantly reduced cardiac cell apoptosis (

Indexed as

AnimalsApoptosisbcl-2 Homologous Antagonist-Killer Proteinbcl-X ProteinCell DeathGene Expression RegulationHumansMiceMice, TransgenicMyocardial InfarctionMyocardiumMyocytes, CardiacProto-Oncogene Proteins c-bcl-2Serine EndopeptidasesVentricular RemodelingBak1 protein, mousebcl-2 Homologous Antagonist-Killer ProteinBcl2l1 protein, mouseBcl2 protein, mousebcl-X ProteinCorin protein, mouseProto-Oncogene Proteins c-bcl-2Serine EndopeptidasesapoptosisBcl-2 family proteincorinmyocardial infarction

Identifiers

PMID32422879
PMCPMC7278931
OpenAlexW3024830277

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.