Evidence map›Paper›PMID 32422644›Full record

ArticlePediatric research2021

Urinary Cystatin-C, a marker to assess and monitor neonatal kidney maturation and function: validation in twins.

Antonella Barbati, Maria Cristina Aisa, Benito Cappuccini, Mariarosalba Zamarra, Sandro Gerli, Gian Carlo Di Renzo

Abstract readTwin StudyValidation Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Trial
  2. Neonatal acute kidney injury: where are we now?Pediatric nephrology (Berlin, Germany) · 2026
    Review
  3. Article
  4. Review
  5. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Antonella BarbatiDepartment of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy. antonella.barbati@unipg.it.
Maria Cristina AisaDepartment of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.
Benito CappucciniGEBISA, Research Foundation, Perugia, Italy.
Mariarosalba ZamarraDepartment of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.
Sandro GerliDepartment of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.
Gian Carlo Di RenzoDepartment of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy.
University of Perugia · ITAzienda Ospedaliera di Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNephrogenesis is a complex process of nephron formation and maturation that can be compromised by preterm delivery and intrauterine growth restriction. This study aimed to evaluate and compare urinary Cys-C levels with renal volume in a cohort of preterm and term twins, adequate for gestational age or intrauterine growth restricted, to investigate their values in different conditions of nephrogenesis.

methodsThe study was performed on twins at 30-40 days of postnatal corrected age: renal volumes were measured by 3D ultrasound technology and urine samples were analyzed for Cystatin-C. A follow-up was performed by Cystatin-C.

resultsRenal volumes in preterm and intrauterine growth-restricted twins showed values significantly lower than those observed in term twins and were inversely correlated to urinary Cystatin-C levels. During the follow-up, intrauterine growth-restricted twins showed amplified levels of urinary Cystatin-C; in contrast, invariable or decreased levels were observed in adequate for gestational age twins.

conclusionsUrinary Cystatin-C, evaluated when intrauterine/extrauterine nephrogenesis could be considered completed, concurrently with renal volume assessment can improve the identification of neonates with initial kidney impairment. Its potential value as a useful marker in monitoring physiological/pathological renal conditions could be considered, mainly for neonates at elevated risk of developing long-term renal diseases. IMPACT: Urinary Cys-C levels are inversely correlated to renal volumes and reflect nephrogenesis conditions. No data in literature are reported regarding: (a) the concurrent assessment of renal volumes and urinary levels of Cystatin-C in preterm and term twins with different conditions of gestational life, i.e., AGA and IUGR and (b) the follow-up of IUGR and preterm neonates using the urinary Cys-C determination. The variations of urinary Cys-C levels, observed in the follow-up of preterm and/or IUGR neonates, support the usefulness of monitoring those neonates with altered nephrogenesis, who are later at risk for renal impairment and for long-term renal diseases.

Indexed as

BiomarkersCystatin CFetal Growth RetardationFollow-Up StudiesGestational AgeHumansInfantInfant, NewbornInfant, PrematureItalyKidneyKidney DiseasesNephronsOrganogenesisProspective StudiesRiskBiomarkersCystatin C

Identifiers

PMID32422644
OpenAlexW3025983299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.