ReviewDigestion2021
Management of Severe Acute Pancreatitis: An Update.
Review in Digestion, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 3 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- Global research trends in necrotizing pancreatitis: a bibliometric analysis from 2013 to 2024.Frontiers in medicine · 2025Pooled it
- The optimal timing and intervention to reduce mortality for necrotizing pancreatitis: a systematic review and network meta-analysis.World journal of emergency surgery : WJES · 2023Pooled it
- Incidence and prognostic role of pleural effusion in patients with acute pancreatitis: a meta-analysis.Annals of medicine · 2023Pooled it
- Application of refined ICU nursing care in the treatment of severe acute pancreatitis and its impact on clinical outcomes.Langenbeck's archives of surgery · 2025Trial
- Syagrus coronata fixed oil attenuates inflammation, oxidative stress and pulmonary alterations in L-arginine-induced pancreatitis.Inflammopharmacology · 2026Article
- An interpretable XGboost algorithm for predicting 30-day mortality in acute pancreatitis using routine biomarkers.BMC medical research methodology · 2026Article
- Diagnostic and prognostic value of serum Hcy and aMMP-8 levels in patients with acute pancreatitis : Value of serum Hcy and aMMP-8 in AP.Langenbeck's archives of surgery · 2026Article
- Correlation Analysis of Body Muscle-Fat Composition Parameters and CT Severity Index with Disease Severity in Acute Pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Trehalose ameliorates severe acute pancreatitis by modulating gut microbial metabolism.NPJ biofilms and microbiomes · 2026Article
- Acute pancreatitis: mechanisms and therapeutic approaches.Signal transduction and targeted therapy · 2026Review
- A combination of cognitive behavioral therapy and enteral nutrition support is beneficial for patients with severe acute pancreatitis in intensive care unit.Frontiers in medicine · 2026Article
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- EASIX as a moderately effective prognostic marker for mortality in severe acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Effect of microenvironment theory-based nursing on prognosis in intensive care unit patients with postoperative severe acute pancreatitis.World journal of gastrointestinal surgery · 2025Article
- Serum Hsa-miR-4695-5p Serves as a Novel Diagnostic Biomarker for Acute Severe Pancreatitis and Exacerbates Pathological Injury by Targeting SESN2.Digestive diseases and sciences · 2025Article
- Effectiveness of pancreatitis activity score plus coagulation function and serum calcium in predicting the severity and outcome of acute pancreatitis.Pakistan journal of medical sciences · 2025Article
- Rutaecarpine targets F-box and WD repeat domain containing 11 to inhibit inflammatory infiltration and alleviate acute pancreatitis.World journal of gastroenterology · 2025Article
- Application and Value of Percutaneous Catheter Drainage in Contemporary Surgical Treatment of Pancreatic Necrosis.Digestive diseases and sciences · 2025Review
- Diagnostic value of HMGB-1 and acetylcholinesterase in assessing the prognosis of patients with acute pancreatitis.Journal of medical biochemistry · 2025Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSevere acute pancreatitis (AP) continues to be a serious gastrointestinal disease with relevant morbidity and mortality. SUMMARY: Successful clinical management requires close interdisciplinary cooperation and coordination from experienced gastroenterologists, intensive care physicians, surgeons, and radiologists. While the early phase of the disease is characterized by intensive care aspects that focus primarily on treatment of organ failure, later complications are characterized especially by (infected) necrotic collections. Here, we discuss current clinical standards and developments for conservative and interventional management of patients with severe AP. Key messages: Early targeted fluid therapy within the first 48 h is critical to improve the outcome of severe AP. Thoracic epidural analgesia may have prognostically beneficial effects due to suspected anti-inflammatory effects and increased perfusion of splanchnic vessels. Enteral feeding should be started early during severe AP. Persistent organ failure (>48 h) is the strongest predictor of poor prognosis, and local complications such as infected walled-off necrosis should be primarily treated by minimally invasive endoscopic step-up approaches that are usually superior to surgical therapy options.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.