Evidence map›Paper›PMID 32422606›Full record

ArticleAging2020

NF2 deficiency accelerates neointima hyperplasia following vascular injury via promoting YAP-TEAD1 interaction in vascular smooth muscle cells.

Xiongshan Sun, Shuang Li, Xueqing Gan, Ken Chen, Dachun Yang, Yongjian Yang

Open access · greenAbstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiongshan SunDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Shuang LiDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Xueqing GanDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Ken ChenDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Dachun YangDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.
Yongjian YangDepartment of Cardiology, The General Hospital of Western Theater Command, Chengdu 610083, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neurofibromin 2 (NF2), a potent tumor suppressor, is reported to inhibit proliferation in several cell types. The role of NF2 in neointima hyperplasia after vascular injury is unknown. We explored the role of NF2 in proliferation, migration of vascular smooth muscle cell (VSMC) and neointima hyperplasia after vascular injury. NF2 phosphorylation was elevated in VSMC subjected to platelet-derived growth factor (PDGF)-BB and in artery subjected to vascular injury. Mice deficient for

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell ProliferationDNA-Binding ProteinsHyperplasiaMiceMuscle, Smooth, VascularMyocytes, Smooth MuscleNeointimaNeurofibromin 2TEA Domain Transcription FactorsTranscription FactorsVascular RemodelingVascular System InjuriesYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsDNA-Binding ProteinsNeurofibromin 2Nf2 protein, mouseTead1 protein, mouseTEA Domain Transcription FactorsTranscription FactorsYap1 protein, mouseYAP-Signaling Proteinsneointima hyperplasiaNF2TEAD1vascular restenosisYAP

Identifiers

PMID32422606
PMCPMC7288949
OpenAlexW3028247965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.