Evidence map›Paper›PMID 32422323›Full record

ArticleNeurochemistry international2020

Evaluation of neurological effects of cerium dioxide nanoparticles doped with different amounts of zirconium following inhalation exposure in mouse models of Alzheimer's and vascular disease.

Tina Wahle, Adriana Sofranko, Susan Dekkers, Mark R Miller, Harm J Heusinkveld, Catrin Albrecht, Flemming R Cassee, Roel P F Schins

Open access · hybridAbstract read
In one paragraph

Article in Neurochemistry international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 32 citations in OpenAlex.

  1. Review
  2. Modulatory effects of CeOParticle and fibre toxicology · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Nanomedicine: A Promising Way to Manage Alzheimer's Disease.Frontiers in bioengineering and biotechnology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Tina WahleIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Adriana SofrankoIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Susan DekkersNational Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Mark R MillerCentre for Cardiovascular Science & Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom.
Harm J HeusinkveldIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany; National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
Catrin AlbrechtIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany.
Flemming R CasseeNational Institute for Public Health and the Environment, Bilthoven, the Netherlands; Institute for Risk Assessment Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands.
Roel P F SchinsIUF - Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany. Electronic address: Roel.Schins@uni-duesseldorf.de.
Leibniz Institute of Environmental Medicine · DENational Institute for Public Health and the Environment · NLCentre for Inflammation Research · GBUtrecht University · NL

Funding

British Heart Foundation CH/09/002British Heart Foundation CH/09/002/26360British Heart Foundation SP/15/8/31575
6 · The paper itself

Abstract

Increasing evidence from toxicological and epidemiological studies indicates that the brain is an important target for ambient (ultrafine) particles. Disturbance of redox-homeostasis and inflammation in the brain are proposed as possible mechanisms that can contribute to neurotoxic and neurodegenerative effects. Whether and how engineered nanoparticles (NPs) may cause neurotoxicity and promote neurodegenerative diseases such as Alzheimer's disease (AD) is largely unstudied. We have assessed the neurological effects of subacute inhalation exposures (4 mg/m

Indexed as

Inhalation ExposureAlzheimer DiseaseAnimalsCeriumDisease Models, AnimalFemaleMiceMice, Inbred C57BLMice, TransgenicMotor ActivityNanoparticlesVascular DiseasesZirconiumceric oxideCeriumZirconiumAlzheimer's diseaseAmyloid-βCerium dioxideInhalationNanoparticles

Identifiers

PMID32422323
PMCPMC7397505
OpenAlexW3025988711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.