Evidence map›Paper›PMID 32421785›Full record

ArticleAmerican journal of hypertension2020

Prognostic Value of Masked Uncontrolled Hypertension Defined by Different Ambulatory Blood Pressure Criteria.

Francesca Coccina, Anna M Pierdomenico, Chiara Cuccurullo, Jacopo Pizzicannella, Rosalinda Madonna, Oriana Trubiani, Francesco Cipollone, Sante D Pierdomenico

Open access · bronzeAbstract read
In one paragraph

Article in American journal of hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  9. How to unmask masked hypertension: the role of office aortic blood pressure.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Francesca CoccinaDepartment of Medical, Oral and Biotechnological Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
Anna M PierdomenicoDepartment of Medicine and Aging Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
Chiara CuccurulloDepartment of Medicine and Aging Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
Jacopo PizzicannellaDepartment of Medical, Oral and Biotechnological Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
Rosalinda MadonnaDepartment of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Oriana TrubianiDepartment of Medical, Oral and Biotechnological Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
Francesco CipolloneDepartment of Medicine and Aging Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
Sante D PierdomenicoDepartment of Medical, Oral and Biotechnological Sciences, University "Gabriele d'Annunzio", Chieti-Pescara, Chieti, Italy.
University of Chieti-Pescara · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMasked uncontrolled hypertension (MUCH), that is, nonhypertensive clinic but high out-of-office blood pressure (BP) in treated patients is at increased cardiovascular risk than controlled hypertension (CH), that is, nonhypertensive clinic and out-of-office BP. Using ambulatory BP, MUCH can be defined as daytime and/or nighttime and/or 24-hour BP above thresholds. It is unclear whether different definitions of MUCH have similar prognostic information. This study assessed the prognostic value of MUCH defined by different ambulatory BP criteria.

methodsCardiovascular events were evaluated in 738 treated hypertensive patients with nonhypertensive clinic BP. Among them, participants were classified as having CH or daytime MUCH (BP ≥135/85 mm Hg) regardless of nighttime BP (group 1), nighttime MUCH (BP ≥120/70 mm Hg) regardless of daytime BP (group 2), 24-hour MUCH (BP ≥130/80 mm Hg) regardless of daytime or nighttime BP (group 3), daytime MUCH only (group 4), nighttime MUCH only (group 5), and daytime + nighttime MUCH (group 6).

resultsWe detected 215 (29%), 357 (48.5%), 275 (37%), 42 (5.5%),184 (25%) and 173 (23.5%) patients with MUCH from group 1 to 6, respectively. During the follow-up (10 ± 5 years), 148 events occurred in patients with CH and MUCH. After adjustment for covariates, compared with patients with CH, the adjusted hazard ratio (95% confidence interval) for cardiovascular events was 2.01 (1.45-2.79), 1.53 (1.09-2.15), 1.69 (1.22-2.34), 1.52 (0.80-2.91), 1.15 (0.74-1.80), and 2.29 (1.53-3.42) from group 1 to 6, respectively.

conclusionsThe prognostic impact of MUCH defined according to various ambulatory BP definitions may be different.

Indexed as

Blood Pressure Monitoring, AmbulatoryAgedAntihypertensive AgentsCircadian RhythmDeath, SuddenFemaleHeart FailureHospitalizationHumansHypertensionMaleMasked HypertensionMiddle AgedMyocardial InfarctionMyocardial RevascularizationPeripheral Vascular DiseasesAntihypertensive Agentsblood pressureclassificationhypertensionmasked hypertensionrisk

Identifiers

PMID32421785
PMCPMC7402227
OpenAlexW3026530837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.