Evidence map›Paper›PMID 32421781›Full record

ArticleAmerican journal of hypertension2020

Aortic Hemodynamics and Cognitive Performance in Postmenopausal Women: Impact of Pregnancy History.

Kathleen B Miller, Julie A Fields, Ronée E Harvey, Brian D Lahr, Kent R Bailey, Michael J Joyner, Virginia M Miller, Jill N Barnes

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Article in American journal of hypertension, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Article
  4. Review
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kathleen B MillerDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Ronée E HarveyDepartment of Internal Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
Brian D LahrDepartment of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
Kent R BaileyDepartment of Health Science Research, Mayo Clinic, Rochester, Minnesota, USA.
Michael J JoynerDepartment of Anesthesiology, Mayo Clinic, Rochester, Minnesota, USA.
Virginia M MillerDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA.
Jill N BarnesDepartment of Kinesiology, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KAPOOR, EKTA · 2018 to 2022
$7.7M
NCATS NIH HHS UL1 TR000135NIA NIH HHS U54 AG044170
6 · The paper itself

Abstract

backgroundStudies demonstrate an association between aortic hemodynamics and cognitive function. The impact of pregnancy history on this association is unknown.

methodsPostmenopausal women (age 59 ± 5 years; years since last pregnancy 35 ± 3) with either a history of preeclampsia (PE; n = 34) or a history of a normotensive pregnancy (NP; n = 30) underwent cognitive testing: Letter-Number Sequencing, Digit Span, Trail Making Test, and letter and category fluency. Applanation tonometry was used to derive aortic systolic and diastolic blood pressure and augmentation index.

resultsDistribution of cognitive scores and aortic hemodynamic measures was similar between the PE and NP groups. Principal component (PC) analysis was used to reduce the 3 aortic hemodynamic measures and the 5 cognitive variables to single summary indices, each representing a weighted average of their respective constituent variables. Using a multivariable linear model based on these PCs that adjusted for pregnancy history and body mass index, the composite index of aortic hemodynamics was associated with the summary cognitive index, whether taking into account a potential interaction with pregnancy history (P = 0.035) or not (P = 0.026) (interaction P = 0.178). Multivariable modeling of individual cognitive tests revealed a differential association for letter fluency by pregnancy history (test for interaction P = 0.023); this score correlated with the aortic hemodynamic index in the PE (partial R2 = 0.20), but not the NP (partial R2 = 0.00) group.

conclusionsElevated aortic hemodynamics may negatively impact cognitive function in postmenopausal women with specific executive functions, such as letter fluency, being impacted more by a pregnancy history of PE.

Indexed as

Reproductive HistoryAortaArterial PressureCardiovascular DiseasesCognitionCognitive DysfunctionFemaleHemodynamicsHumansLinear ModelsManometryMiddle AgedMultivariate AnalysisNeuropsychological TestsPostmenopausePre-Eclampsiaaortic stiffnessblood pressurecognitionhypertensionmenopausepreeclampsiapregnancy

Identifiers

PMID32421781
PMCPMC7402228

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.