ArticlePloS one2020
Increased financial burdens and lengths of stay in patients with healthcare-associated infections due to multidrug-resistant bacteria in intensive care units: A propensity-matched case-control study.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Implementation of patient safety monitoring systems in hospitals: a systematic review.BMJ health & care informatics · 2025Pooled it
- Antibiotics for hospital-acquired pneumonia in neonates and children.The Cochrane database of systematic reviews · 2021Pooled it
- Convergent Architecture of thePathogens (Basel, Switzerland) · 2026Article
- Review of risk factors and prediction models for multidrug-resistant bacterial pulmonary infections in patients with chronic obstructive pulmonary disease.The Journal of international medical research · 2026Review
- Early Factors Related to Healthcare Utilization by Infection Status among Combat Injured.Military medicine · 2026Article
- Application of the infection risk scan in an intensive care unit.Antimicrobial resistance and infection control · 2026Observational
- Economic burden of hospital-acquired multidrug-resistant organism infections in patients undergoing gastrointestinal surgery: a bootstrap-based retrospective cohort study.Frontiers in public health · 2026Article
- Improved time-to-detection with the new formulation of BD BACTEC Plus Aerobic/F Culture Vials: a real-world evidence study.Microbiology spectrum · 2025Article
- Culture Positivity and Antibiotic Resistance in Respiratory Intensive Care Patients: Evaluation of Readmission and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2025Article
- Development and validation of an interpretable nomogram for predicting the risk of the prolonged postoperative length of stay for tuberculous spondylitis: a novel approach for risk stratification.BMC musculoskeletal disorders · 2025Article
- Strategies to Reduce Hospital Length of Stay: Evidence and Challenges.Medicina (Kaunas, Lithuania) · 2025Review
- Evaluation of the disease burden of nosocomial infection among inpatients in a cancer hospital based on propensity score matching.Frontiers in public health · 2025Article
- Preventing and Controlling Healthcare-Associated Infections: The First Principle of Every Antimicrobial Stewardship Program in Hospital Settings.Antibiotics (Basel, Switzerland) · 2024Review
- Streamlining patient flow and enhancing operational efficiency through case management implementation.BMJ open quality · 2024Article
- Hand Hygiene Compliance and Its Associated Factors Among Health Care Workers at Mogadishu Somali Turkiye Recep Tayyip Erdoğan Training and Research in a Tertiary Care Hospital.Risk management and healthcare policy · 2024Article
- Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria.International journal of molecular sciences · 2023Article
- Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2017-2021.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2023Article
- Healthcare-associated infections and antimicrobial resistance in Canadian acute care hospitals, 2016-2020.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2022Article
- Antibiotic Stewardship Related to Delayed Diagnosis and Poor Prognosis of Critically Ill Patients with Vancomycin-Resistant Enterococcal Bacteremia: A Retrospective Cohort Study.Infection and drug resistance · 2022Article
- Progression of Fibrinogen Decrease during High Dose Tigecycline Therapy in Critically Ill Patients: A Retrospective Analysis.Journal of clinical medicine · 2021Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesIncidence rates of healthcare-associated infections (HAIs) depend upon infection control policy and practices, and the effectiveness of the implementation of antibiotic stewardship. Amongst intensive care unit (ICU) patients with HAIs, a substantial number of pathogens were reported to be multidrug-resistant bacteria (MDRB). However, impacts of ICU HAIs due to MDRB (MDRB-HAIs) remain understudied. Our study aimed to evaluate the negative impacts of MRDB-HAIs versus HAIs due to non-MDRB (non-MRDB-HAIs).
methodsAmong 60,317 adult patients admitted at ICUs of a 2680-bed medical centre in Taiwan between January 2010 and December 2017, 279 pairs of propensity-score matched MRDB-HAI and non-MRDB-HAI were analyzed. PRINCIPAL
findingsBetween the MDRB-HAI group and the non-MDRB-HAI group, significant differences were found in overall hospital costs, costs of medical and nursing services, medication, and rooms/beds, and in ICU length-of-stay (LOS). As compared with the non-MDRB-HAI group, the mean of the overall hospital costs of patients in the MDRB-HAI group was increased by 26%; for categorized expenditures, the mean of costs of medical and nursing services of patients in the MDRB-HAI group was increased by 8%, of medication by 26.9%, of rooms/beds by 10.3%. The mean ICU LOS in the MDRB-HAI group was increased by 13%. Mortality rates in both groups did not significantly differ.
conclusionsThese data clearly demonstrate more negative impacts of MDRB-HAIs in ICUs. The quantified financial burdens will be helpful for hospital/government policymakers in allocating resources to mitigate MDRB-HAIs in ICUs; in case of need for clarification/verification of the medico-economic burdens of MDRB-HAIs in different healthcare systems, this study provides a model to facilitate the evaluations.
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