Evidence map›Paper›PMID 32421532›Full record

ArticlePlacenta2020

Wharton's jelly area and its association with placental morphometry and pathology.

Sarah K Debebe, Lindsay S Cahill, John C Kingdom, Clare L Whitehead, Anjana Ravi Chandran, W Tony Parks, Lena Serghides, Ahmet Baschat, Christopher K Macgowan, John G Sled

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Placenta, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
13.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Sarah K DebebeMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada. Electronic address: sarah.debebe@mail.utoronto.ca.
Lindsay S CahillMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada.
John C KingdomDepartment of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Mount Sinai Hospital, Toronto, Ontario, Canada.
Clare L WhiteheadMount Sinai Hospital, Toronto, Ontario, Canada.
Anjana Ravi ChandranMount Sinai Hospital, Toronto, Ontario, Canada.
W Tony ParksDepartment of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Mount Sinai Hospital, Toronto, Ontario, Canada.
Lena SerghidesToronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada; Department of Immunology and Institute of Medical Sciences, University of Toronto, Ontario, Canada; Women's College Research Institute, Women's College Hospital, Toronto, Ontario, Canada.
Ahmet BaschatCentre for Fetal Therapy, Johns Hopkins Medicine, Baltimore, MD, USA.
Christopher K MacgowanDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
John G SledMouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
University of Toronto · CAMount Sinai Hospital · CAHospital for Sick Children · CAJohns Hopkins University · US

Funding

Environmental factors in placental pathology: a new diagnostic method based on umbilical vessel wave mechanicsU01HD087177 · NICHD · HOSPITAL FOR SICK CHLDRN (TORONTO) · PI SLED, JOHN G · 2015 to 2015
$2.5M
CIHR PJT-153202NICHD NIH HHS U01 HD087177
6 · The paper itself

Abstract

introductionWharton's jelly (WJ) is the mucoid connective tissue that surrounds the vessels in the human umbilical cord and provides protection from compression and torsion in response to fetal movement. WJ is known to be altered in the presence of pregnancy complications such as gestational diabetes mellitus and preeclampsia. The present study examined associations between the cross-sectional area of WJ measured by ultrasound and postpartum placental pathology and morphometry.

methodsThe area of WJ was measured by ultrasound in 156 eligible participants between 23 and 37 weeks' gestation. Morphometric assessment of fixed cord cross sections was conducted, together with assessment of the cord and placenta for specific pathologies using standard criteria.

resultsFrom 156 participants, 123 ultrasound images met the data quality requirements and pathology reporting was completed for 99 placentas. 17 of the participants (14%) delivered a small for gestational age neonate and 32 of the 99 placentas examined (32%) had significant placental pathology findings. Area of WJ was associated with low birth weight (p = 0.002) and was associated with specific placental pathology (p = 0.01). WJ area was positively associated with placental dimensions such as width, length and surface area. DISCUSSION: Decreased WJ area is associated with clinically-significant placental pathology and WJ area scales proportionally with placental size. These findings suggest that WJ area correlates with functional capacity of the placenta and thus merits further evaluation alongside currently-available tests of placental function in clinical practice.

Indexed as

Ultrasonography, PrenatalAdultDiabetes, GestationalFemaleGestational AgeHumansInfant, Low Birth WeightInfant, Small for Gestational AgePlacentaPre-EclampsiaPregnancyPregnancy OutcomeUmbilical CordWharton JellyMorphometryPlacental pathologyUltrasoundUmbilical cordWharton's jelly

Identifiers

PMID32421532
PMCPMC7491570
OpenAlexW3013372964

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.