Trial reportJournal of clinical oncology : official journal of the American Society of Clinical Oncology2020
Implementation of Minimally Invasive Esophagectomy From a Randomized Controlled Trial Setting to National Practice.
Trial report in Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Comparative analysis of robot-assisted minimally invasive esophagectomy versus conventional minimally invasive esophagectomy, a systematic review and meta-analysis.Journal of robotic surgery · 2025Pooled it
- The influence of minimally invasive esophagectomy on wound infection in patients undergoing esophageal cancer surgery: A meta-analysis.International wound journal · 2024Pooled it
- Physiotherapy Regimens in Esophagectomy and Gastrectomy: a Systematic Review and Meta-Analysis.Annals of surgical oncology · 2022Pooled it
- Impact of Excess Body Weight on Postsurgical Complications.Visceral medicine · 2021Pooled it
- Article
- Evolution and refinements in minimally invasive esophagectomy: a narrative review.Journal of thoracic disease · 2026Review
- Decreasing Complications After Ivor-Lewis Esophagectomy: Is a Totally Minimally Invasive Approach the Solution?Journal of surgical oncology · 2025Article
- Postoperative outcomes after minimally invasive esophagectomy: an international cohort study from the Oesophagogastric Anastomosis Audit (OGAA).BMC surgery · 2025Article
- Preoperative immune prognostic index predicts the prognosis and postoperative adjuvant chemotherapy benefits of esophageal squamous cell carcinoma after minimally invasive esophagectomy.BMC gastroenterology · 2025Article
- Colonic hiatal hernia leading to obstruction after minimally invasive McKeown esophagectomy: a case report.Frontiers in surgery · 2025Review
- Establishment and validation of survival nomogram score staging for esophageal squamous cell carcinoma patients after minimally invasive surgery combined with immune prognostic index and clinicopathological features.Frontiers in immunology · 2025Article
- National validation of laparoscopic approach for locally advanced gastric cancer: Comparison of a randomized controlled trial and real-world practice results.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024Article
- Article
- Current Gallstone Treatment Methods, State of the Art.Diseases (Basel, Switzerland) · 2024Review
- Surgical options in retrosternal oesophageal reconstruction.Langenbeck's archives of surgery · 2024Article
- History and evidence for state of the art of lymphadenectomy in esophageal cancer surgery.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Review
- The impact of hospital experience in bariatric surgery on short-term outcomes after minimally invasive esophagectomy: a nationwide analysis.Surgical endoscopy · 2024Article
- Introduction of Minimally Invasive transCervical oEsophagectomy (MICE) according to the IDEAL framework.The British journal of surgery · 2023Article
- Endoscopic vacuum therapy significantly improves clinical outcomes of anastomotic leakages after 2-stage, 3-stage, and transhiatal esophagectomies.Langenbeck's archives of surgery · 2023Article
- The Implementation of Minimally Invasive Surgery in the Treatment of Esophageal Cancer: A Step Toward Better Outcomes?Oncology and therapy · 2022Review
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeThe aim of this study was to examine the external validity of the randomized TIME trial, when minimally invasive esophagectomy (MIE) was implemented nationally in the Netherlands, using data from the Dutch Upper GI Cancer Audit (DUCA) for transthoracic esophagectomy.
methodsOriginal patient data from the TIME trial were extracted along with data from the DUCA dataset (2011-2017). Multivariate analysis, with adjustment for patient factors, tumor factors, and year of surgery, was performed for the effect of MIE versus open esophagectomy on clinical outcomes.
resultsOne hundred fifteen patients from the TIME trial (59 MIE
conclusionWhen adopted nationally outside the TIME trial, MIE was associated with an increase in total and pulmonary complications and reoperation rate. This may reflect nonexpert surgeons outside of high-volume centers performing this minimally invasive technique in a nonstandardized fashion outside of a controlled environment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.