Evidence map›Paper›PMID 32421193›Full record

ArticleAnnals of behavioral medicine : a publication of the Society of Behavioral Medicine2021

Ethnic Differences in Experimental Pain Responses Following a Paired Verbal Suggestion With Saline Infusion: A Quasiexperimental Study.

Janelle E Letzen, Troy C Dildine, Chung Jung Mun, Luana Colloca, Stephen Bruehl, Claudia M Campbell

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Article in Annals of behavioral medicine : a publication of the Society of Behavioral Medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Janelle E LetzenDepartment of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Nathan Shock Drive, Suite, Baltimore, MD, USA.
Troy C DildineNational Center for Complementary and Integrative Health, National Institutes of Health, Bethesda, MD, USA.
Chung Jung MunDepartment of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Nathan Shock Drive, Suite, Baltimore, MD, USA.
Luana CollocaDepartment of Pain and Translational Symptom Science, School of Nursing, University of Maryland, Baltimore, MD, USA.
Stephen BruehlDepartment of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, USA.
Claudia M CampbellDepartment of Psychiatry and Behavioral Science, Johns Hopkins University School of Medicine, Nathan Shock Drive, Suite, Baltimore, MD, USA.

Funding

Reduced Opioid Analgesic Requirements Via Improved Endogenous Opioid FunctionR01DA037891 · NIDA · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRUEHL, STEPHEN, BURNS, JOHN W. · 2015 to 2018
$2.6M
Ethnic differences in endogenous pain regulation: PET imaging of opioid receptorsR01MD009063 · NIMHD · JOHNS HOPKINS UNIVERSITY · PI CAMPBELL, CLAUDIA MICHELLE · 2014 to 2018
$2.1M
Neural mechanisms of treatment motivation and adherence in sickle cell diseaseF32HL143941 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LETZEN, JANELLE E · 2018 to 2019
$129k
Evaluating dynamic associations between pain catastrophizing and the effect of cannabinoidsF32DA049393 · NIDA · JOHNS HOPKINS UNIVERSITY · PI MUN, CHUNG JUNG · 2019 to 2020
$127k
Ethnic differences in effects of opioid blockade and behavioral analgesia on painF32NS063624 · NINDS · JOHNS HOPKINS UNIVERSITY · PI CAMPBELL, CLAUDIA MICHELLE · 2008 to 2009
$95k
NHLBI NIH HHS F32 HL143941NIDA NIH HHS F32 DA049393NIDA NIH HHS R01 DA037891NIMHD NIH HHS R01 MD009063NINDS NIH HHS F32 NS063624
6 · The paper itself

Abstract

backgroundEthnic differences in placebo and nocebo responses are an important, yet underresearched, patient factor that might contribute to treatment disparities. PURPOSE: The purpose of this study was to examine ethnic differences in pain trajectories following a verbal suggestion paired with a masked, inert substance (i.e., saline).

methodsUsing a quasiexperimental design, we examined differences between 21 non-Hispanic Black (NHB) participants and 20 non-Hispanic White (NHW) participants in capsaicin-related pain rating trajectories following a nondirectional verbal suggestion + saline infusion. All participants were told that the substance would "either increase pain sensation, decrease it, or leave it unchanged." A spline mixed model was used to quantify the interaction of ethnicity and time on ratings.

resultsThere was a significant Ethnicity × Time interaction effect (β = -0.28, p = .002); NHB individuals reported significantly greater increases in pain following, but not before, the verbal suggestion + saline infusion. Sensitivity analyses showed no change in primary results based on differences in education level, general pain sensitivity, or condition order.

conclusionsThe present results showed ethnic differences in pain response trajectories following a verbal suggestion + saline infusion and suggest that future research rigorously examining possible ethnic differences in placebo/nocebo responses is warranted.

Indexed as

Pain MeasurementPain PerceptionAdultCapsaicinEthnicityFemaleHumansMaleNocebo EffectPainPlacebo EffectSaline SolutionSuggestionCapsaicinSaline SolutionEthnic differenceExperimental painNoceboPain disparitiesPlaceboSpline model

Identifiers

PMID32421193
PMCPMC7880220

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.