ReviewActa bio-medica : Atenei Parmensis2020
Frailty syndrome in rheumatoid arthritis and symptomatic osteoarthritis: an emerging concept in rheumatology.
Review in Acta bio-medica : Atenei Parmensis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Frailty in people with rheumatoid arthritis: a systematic review of observational studies.Wellcome open research · 2021Pooled it
- Swedish massage versus hip strengthening exercises for pain and function in older adults with knee osteoarthritis: a randomized controlled trial.Aging clinical and experimental research · 2026Trial
- Evaluating a Pragmatic Strength Alternative for Frailty Measurement and Assessing Its Predictive Capacity Against Established Frailty Instruments in Rheumatoid Arthritis.Arthritis care & research · 2026Article
- Five Factors of Frailty: A Multidimensional Psychometrically Robust Research Tool.Research square · 2026Article
- Resistance-based exercise restores muscle health in dialysis patients.Journal of muscle research and cell motility · 2026Article
- Insights Into Late-Onset Rheumatoid Arthritis (LORA): Characteristics (Clinical and Imaging), Comorbidities, and Therapeutic Targets.Geriatrics & gerontology international · 2026Review
- Frailty in rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis: Current evidence and knowledge gaps.Therapeutic advances in musculoskeletal disease · 2026Review
- Article
- Association of Frailty with Ultrasound Parameters of Diaphragm Function in 153 Elderly Individuals.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- On the edge of dependency: how older adults with rheumatoid arthritis experience living with frailty.EULAR rheumatology open · 2025Article
- Prevalence of frailty and associated factors in Shanghai older community-dwelling adults: a cross-sectional study.BMJ open · 2025Article
- The association between metabolic syndrome severity and frailty risk in patients with rheumatoid arthritis: a cross-sectional study.Arthritis research & therapy · 2025Article
- What happens to conservatively managed chronic subdural haematoma.Acta neurochirurgica · 2025Article
- Osteosarcopenia, osteoarthritis and frailty: a two-sample Mendelian randomization study.Aging clinical and experimental research · 2025Article
- A Mediation Appraisal of Neuropathic-like Symptoms, Pain Catastrophizing, and Central Sensitization-Related Signs in Adults with Knee Osteoarthritis-A Cross-Sectional Study.Journal of personalized medicine · 2025Article
- Late-Onset Rheumatoid Arthritis (LORA): A Diagnostic and Therapeutic Challenge Among Older Patients Visiting a Poorly Resourced Health-Care Setting.Mediterranean journal of rheumatology · 2024Review
- Unveiling the Hidden Links: Anatomical and Radiological Insights into Primary Hip Osteoarthritis.Journal of personalized medicine · 2024Article
- Advanced Heart Failure Therapies in Neuromuscular Diseases.Current treatment options in cardiovascular medicine · 2024Article
- Adaptation of the comprehensive rheumatologic assessment of frailty (CRAF) as a multidimensional frailty screening tool in patients with rheumatoid arthritis in Vietnam.BMC rheumatology · 2024Article
- Preoperative frailty predicts postoperative pain after total knee arthroplasty in older patients: a prospective observational study.European geriatric medicine · 2024Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Musculoskeletal conditions such as rheumatoid arthritis (RA) and symptomatic osteoarthritis (OA) were the leading cause of disability in developed countries and disproportionately affects older adults. Frailty is an emerging concept in rheumatology, which represents an important construct to aid in the identification of in- dividuals who are vulnerable to adverse events and less favourable outcomes. The prevalence of frailty among the community-dwelling population increases with age: it ranges from 7% to 10% in those aged over 65 years and to 20-40% among octogenarians. Among patients with RA, the prevalence of frailty is comparable to, or even greater, that of older geriatric cohorts and pre-frailty, a condition including a major health vulnerability between robust and frail, is much more prevalent in RA than in geriatric cohorts. Clinical OA is also associated with frailty and pre-frailty in older adults in European countries. The overall prevalence of clinical OA at any site was 30.4%; frailty was present in 10.2% and pre-frailty in 51.0 %. The diagnosis of frailty is usually clinical and based on specific criteria, which are sometimes inconsistent. Therefore, there is an increasing need to identify and vali- date robust biomarkers for this condition. In the literature, different criteria have been validated to identify frail older subjects, which mainly refer to two conceptual models: the Physical Frailty (PF) phenotype proposed by Fried and the cumulative deficit approach proposed by Rockwood. The purpose of this review was to quantita- tively synthesize published literature on the prevalence of frailty in RA and OA and summarize current evidence on the validity and practicality of the most commonly used screening tools for frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.