ArticleJournal of medicinal chemistry2020
A γ-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli.
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Article in Journal of medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
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Who cites it
10 citing papers in PubMed, 32 citations in OpenAlex.
- Novel analogues of a nonnucleoside SARS-CoV-2 RdRp inhibitor as potential antivirotics.Beilstein journal of organic chemistry · 2024Article
- Enhancement of growth media for extreme iron limitation in Escherichia coli.Access microbiology · 2024Article
- Penicillin-binding protein (PBP) inhibitor development: A 10-year chemical perspective.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Siderophore conjugates to combat antibiotic-resistant bacteria.RSC medicinal chemistry · 2023Review
- Identification ofAntibiotics (Basel, Switzerland) · 2022Article
- A γ-lactam siderophore antibiotic effective against multidrug-resistant Pseudomonas aeruginosa, Klebsiella pneumoniae, and Acinetobacter spp.European journal of medicinal chemistry · 2021Article
- Advances in Understanding of the Copper Homeostasis inInternational journal of molecular sciences · 2021Review
- Article
- Article
- Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.Molecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
23 authors at 7 institutions in 1 country.
Joel A GoldbergResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Ha NguyenDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Vijay KumarDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Elizabeth J SpencerYale Center for Molecular Discovery, West Haven, Connecticut 06516, United States.
Denton HoyerYale Center for Molecular Discovery, West Haven, Connecticut 06516, United States.
Emma K MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Anna CmolikResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Margaret O'SheaResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Steven H MarshallResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Andrea M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Kristine M HujerResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Susan D RudinResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
T Nicholas DomitrovicResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Christopher R BethelResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Krisztina M Papp-WallaceResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Latania K LoganDepartment of Pediatrics, Rush University Medical Center, Rush Medical College, Chicago, Illinois 60612, United States.
Federico PerezResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.
Michael R JacobsDepartment of Medicine, Case Western Reserve University, Cleveland, Ohio 44106, United States.
David van DuinUniversity of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, United States.
Barry M KreiswirthCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07601, United States.
Robert A BonomoResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States.ORCID 0000-0002-3299-894X
Mark S PlummerYale Center for Molecular Discovery, West Haven, Connecticut 06516, United States.
Focco van den AkkerDepartment of Biochemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States.
Louis Stokes Cleveland VA Medical Center · USCase Western Reserve University · USGeriatric Research Education and Clinical Center · USHackensack Meridian Health · USRush University Medical Center · USUniversity Hospitals of Cleveland · USUniversity of North Carolina at Chapel Hill · US
Funding
Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MX-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6MThe molecular basis of the epidemic blaKPC gene KlebsiellaR01AI090155 · NIAID · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI KREISWIRTH, BARRY NEAL · 2011 to 2021
$7.2MUnderstanding B-Lactam Resistance in Acinetobacter baumanniiR01AI072219 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI ROBERT A. BONOMO, Philip N. Rather · 2007 to 2026
$6.6MUnderstanding ceftazidime resistance in SHV B-LactamasesR01AI063517 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A. · 2005 to 2023
$4.9MA Mechanism-Based Approach to Metallo-beta-Lactamase InhibitionR01AI100560 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI BONOMO, ROBERT A., SPENCER, JAMES · 2012 to 2022
$4.4MThe Epidemiology of Multi-Drug Resistant Enterobacteriaceae Infections in ChildreK08AI112506 · NIAID · RUSH UNIVERSITY MEDICAL CENTER · PI LOGAN, LATANIA K. · 2014 to 2018
$916kThe Continuing Challenge of Carbapenemases in K. pneumoniae: KPC-2 & NDM-1I01BX001974 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI BONOMO, ROBERT A. · 2013 to 2024
–Targeting Burkholderial β-lactamases: Structure, function, and regulationI01BX002872 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI DONSKEY, CURTIS, PAPP-WALLACE, KRISZTINA MARGARET · 2016 to 2023
–BLRD VA I01 BX001974BLRD VA I01 BX002872NCATS NIH HHS UL1 TR001863NIAID NIH HHS K08 AI112506NIAID NIH HHS R01 AI063517NIAID NIH HHS R01 AI072219NIAID NIH HHS R01 AI090155NIAID NIH HHS R01 AI100560NIAID NIH HHS UM1 AI104681NIGMS NIH HHS P41 GM103393
Abstract
Treatment of multidrug-resistant Gram-negative bacterial pathogens represents a critical clinical need. Here, we report a novel γ-lactam pyrazolidinone that targets penicillin-binding proteins (PBPs) and incorporates a siderophore moiety to facilitate uptake into the periplasm. The MIC values of γ-lactam YU253434,
Indexed as
AnimalsAnti-Bacterial AgentsBacterial ProteinsBinding SitesCatalytic DomainCrystallography, X-RayDrug Resistance, Multiple, BacterialGram-Negative BacteriaHalf-LifeLactamsMiceMicrobial Sensitivity TestsMolecular Docking SimulationPenicillin-Binding ProteinsPseudomonas aeruginosaSiderophoresAnti-Bacterial AgentsBacterial ProteinsLactamsPenicillin-Binding ProteinsSiderophores
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.