Evidence map›Paper›PMID 32420386›Full record

ArticleBioMed research international2020

The Prediction and Prognostic Significance of INPP5K Expression in Patients with Liver Cancer.

Ruobing Wang, Yan Jiao, Yanqing Li, Siyang Ye, Guoqiang Pan, Shanshan Qin, Fang Hua, Yahui Liu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ruobing WangDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0001-6176-2023
Yan JiaoDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0001-6914-7949
Yanqing LiDepartment of Pathophysiology, College of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0001-7030-5537
Siyang YeDepartment of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin 130022, China.
Guoqiang PanDepartment of Gastrointestinal Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.
Shanshan QinDepartment of Radiology, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, China.
Fang HuaCardiovascular Internal Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0003-2970-1305
Yahui LiuDepartment of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, Jilin 130021, China.ORCID https://orcid.org/0000-0002-4018-5404
Jilin University · CNQingdao University · CNSecond Affiliated Hospital of Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver cancer is a devastating disease for humans with poor prognosis. Although the survival rate of patients with liver cancer has improved in the past decades, the recurrence and metastasis of liver cancer are still obstacles for us. Inositol polyphosphate-5-phosphatase K (INPP5K) belongs to the family of phosphoinositide 5-phosphatases (PI 5-phosphatases), which have been reported to be associated with cell migration, polarity, adhesion, and cell invasion, especially in cancers. However, there have been few studies on the correlation of INPP5K and liver cancer. In this study, we explored the prognostic significance of INPP5K in liver cancer through bioinformatics analysis of data collected from The Cancer Genome Atlas (TCGA) database. Chi-square and Fisher exact tests were used to evaluate the relationship between INPP5K expression and clinical characteristics. Our results showed that low INPP5K expression was correlated with poor outcomes in liver cancer patients. Univariate and multivariate Cox analyses demonstrated that low INPP5K mRNA expression played a significant role in shortening overall survival (OS) and relapse-free survival (RFS), which might serve as the useful biomarker and prognostic factor for liver cancer. In conclusion, low INPP5K mRNA expression is an independent risk factor for poor prognosis in liver cancer.

Indexed as

Databases, Nucleic AcidGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticInositol Polyphosphate 5-PhosphatasesLiver NeoplasmsNeoplasm ProteinsAgedDisease-Free SurvivalFemaleHumansMaleMiddle AgedPredictive Value of TestsSurvival RateInositol Polyphosphate 5-PhosphatasesNeoplasm Proteins

Identifiers

PMID32420386
PMCPMC7201693
OpenAlexW3018667148

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.