Evidence map›Paper›PMID 32420378›Full record

ArticleBioMed research international2020

Propofol Attenuates Hypoxia-Induced Inflammation in BV2 Microglia by Inhibiting Oxidative Stress and NF-

Xiaowei Peng, Chenglong Li, Wei Yu, Shuai Liu, Yushuang Cong, Guibo Fan, Sihua Qi

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 57 citations in OpenAlex.

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  17. Microglia at the blood brain barrier in health and disease.Frontiers in cellular neuroscience · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xiaowei PengDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.
Chenglong LiDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.
Wei YuDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.
Shuai LiuDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.
Yushuang CongDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.
Guibo FanDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.
Sihua QiDepartment of Anesthesiology, The Fourth Affiliated Hospital of the Harbin Medical University, 37 Yiyuan Road, Harbin, 150001 Heilongjiang, China.ORCID https://orcid.org/0000-0002-1481-7498
Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoxia-induced neuroinflammation typically causes neurological damage and can occur during stroke, neonatal hypoxic-ischemic encephalopathy, and other diseases. Propofol is widely used as an intravenous anesthetic. Studies have shown that propofol has antineuroinflammatory effect. However, the underlying mechanism remains to be fully elucidated. Thus, we aimed to investigate the beneficial effects of propofol against hypoxia-induced neuroinflammation and elucidated its potential cellular and biochemical mechanisms of action. In this study, we chose cobalt chloride (CoCl

Indexed as

AnimalsCell HypoxiaCell LineHypoxia-Inducible Factor 1, alpha SubunitMiceMicrogliaOxidative StressPropofolSignal TransductionTranscription Factor RelAHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitPropofolRela protein, mouseTranscription Factor RelA

Identifiers

PMID32420378
PMCPMC7204316
OpenAlexW3022770697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.