ArticleInternational journal of ophthalmology2020
Foveal pit morphological changes in asymptomatic carriers of the G11778A mutation with Leber's hereditary optic neuropathy.
Article in International journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Prediction of postoperative visual acuity in patients with age-related cataracts using macular optical coherence tomography-based deep learning method.Frontiers in medicine · 2023Article
- Photoreceptor changes in Leber hereditary optic neuropathy with m.G11778A mutation.International journal of ophthalmology · 2023Article
- The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy.Journal of clinical medicine · 2022Article
- Photoreceptor Manifestations of Primary Mitochondrial Optic Nerve Disorders.Investigative ophthalmology & visual science · 2022Article
- Mitochondrial Syndromes Revisited.Journal of clinical medicine · 2021Review
- Are foveal thickness, pit depth, and slopes truly abnormal in unaffected carriers of the LHON variant m.11778G>G?International journal of ophthalmology · 2021Article
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Authors and funding
9 authors.
Funding
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Abstract
aimTo investigate the foveal pit morphology changes in unaffected carriers and affected Leber's hereditary optic neuropathy (LHON) patients with the G11778A mutation from one family.
methodsThis study was a prospective cross-sectional study. Both eyes from 16 family members (age from 9 to 47y) with the G11778A mutation were analyzed and compared with 1 eye from 20 normal control subjects. Eleven family members with the G11778A mutation but without optic neuropathy were classified as unaffected carriers (
resultsThicker foveal thickness, thinner foveal pit depth, and flatter foveal slopes were observed in unaffected carriers and affected LHON patients (all
conclusionThe foveal pit morphology shows changes in both unaffected carriers and affects patients. RNFL and GCL+IPL are thinner in affected LHON patients but not in unaffected carriers.
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