Evidence map›Paper›PMID 32420143›Full record

ArticleTranslational andrology and urology2020

Comparison of

Mengxia Chen, Qing Zhang, Chengwei Zhang, Yi-Hua Zhou, Xiaozhi Zhao, Yao Fu, Jie Gao, Bing Zhang, Feng Wang, Xuefeng Qiu and 1 more

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Translational andrology and urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05670691 (A Prospective, Staged, Exploratory Clinical Study of Combined Multiparametric MRI and PSMA PET/CT for the Evaluation of Patients With High Suspicion of Prostate Cancer for Direct Radical Prostatectomy Without Prostate Biopsy), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05670691 unknown statusnot on this mapstarted 2023, after this paper: background citation

A Prospective, Staged, Exploratory Clinical Study of Combined Multiparametric MRI and PSMA PET/CT for the Evaluation of Patients With High Suspicion of Prostate Cancer for Direct Radical Prostatectomy Without Prostate Biopsy

TypeobservationalSponsorFudan UniversityRan2023 to 2025Enrolled71ConditionsProstatic Neoplasms, Prostatectomy, Prostate Biopsy
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Comparison ofFrontiers in oncology · 2024
    Pooled it
  3. Head-to-Head Comparison ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Trial
  4. Article
  5. Utility ofEuropean journal of nuclear medicine and molecular imaging · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. PET/CT imaging 2 h after injection of [European journal of hybrid imaging · 2023
    Article
  12. CanTranslational andrology and urology · 2023
    Article
  13. PSMA PET-CT in the Diagnosis and Staging of Prostate Cancer.Diagnostics (Basel, Switzerland) · 2022
    Review
  14. Review
  15. Comparison ofEuropean urology open science · 2021
    Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Mengxia ChenDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Qing ZhangDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Chengwei ZhangDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Yi-Hua ZhouDepartments of Experimental Medicine and Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China.
Xiaozhi ZhaoDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Yao FuDepartment of Pathology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.
Jie GaoDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Bing ZhangDepartment of Radiology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.
Feng WangDepartment of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
Xuefeng QiuDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Hongqian GuoDepartment of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology, Nanjing University, Nanjing 210008, China.
Nanjing University · CNNanjing Drum Tower Hospital · CNNanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo compare the diagnostic performance of

methodsWe retrospectively enrolled 54 patients with both PET/CT and mpMRI before radical prostatectomy. Diagnostic performance of mpMRI, PET/CT and their combination (com-MRI/PET) on ECE and SVI on a patient basis were analyzed. The impact of additional PET/CT scanning on therapeutic decisions were presented.

resultsAmong the 54 patients, 17 had tumor limited in the prostate gland, 25 only had ECE and 12 patients had both SVI and ECE on pathology. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of ECE were 54%, 94%, 95%, 48% on mpMRI, 78%, 94%, 97%, 67% on PET/CT and 83%, 88%, 94%, 71% on com-MRI/PET. Both PET/CT and com-MRI/PET had a higher sensitivity than mpMRI on ECE diagnosis (78%

conclusions

Indexed as

68Ga-prostate-specific membrane antigen positron emission tomography/computed tomography (68Ga-PSMA PET/CT)extracapsular extension (ECE)multi-parametric magnetic resonance imaging (mpMRI)prostate cancerseminal vesicle invasion (SVI)

Identifiers

PMID32420143
PMCPMC7215027
OpenAlexW3015314953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.