Evidence map›Paper›PMID 32420069›Full record

ArticleTranslational lung cancer research2020

Expression of large tumour suppressor (LATS) kinases modulates chemotherapy response in advanced non-small cell lung cancer.

Susan Yang Luo, Hoi-Hin Kwok, Pan-Chyr Yang, Mary Sau-Man Ip, John Dorrance Minna, David Chi-Leung Lam

Open access · diamondAbstract read
In one paragraph

Article in Translational lung cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. The roles of IKKα in normal physiology and cancer.Cell communication and signaling : CCS · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Susan Yang LuoDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Hoi-Hin KwokDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Pan-Chyr YangDepartment of Internal Medicine, National Taiwan University Hospital, Taipei.
Mary Sau-Man IpDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
John Dorrance MinnaHamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX, USA.
David Chi-Leung LamDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China.
Queen Mary Hospital · CNUniversity of Hong Kong · HKNational Taiwan University Hospital · TWThe University of Texas Southwestern Medical Center · US

Funding

UNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI GIBBONS, DON LYNN · 1996 to 2024
$57.4M
NCI NIH HHS P50 CA070907
6 · The paper itself

Abstract

backgroundThe Hippo signalling pathway plays an important role in regulating organ size and cell proliferation. Down-regulation of large tumour suppressor (LATS) protein homologs

methodsIn lung adenocarcinoma (AD) cells, protein expression of

resultsManipulation of the expression of these two

conclusionsOur data suggested that the ratio of expression of

Indexed as

Hippolarge tumour suppressor (LATS)lung cancer

Identifiers

PMID32420069
PMCPMC7225163
OpenAlexW3016116354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.