ArticleTranslational lung cancer research2020
DNA methylation markers that correlate with occult lymph node metastases of non-small cell lung cancer and a preliminary prediction model.
Article in Translational lung cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed.
- Methylated circulating tumor DNA: technical challenges and clinical applications in non-small cell lung cancer patients-a narrative review.Translational lung cancer research · 2026Review
- NHOC/NHOP as novel biomarkers for predicting lymph node metastasis in NSCLC using PET/CT radiomics and machine learning: a two-center retrospective study.European journal of nuclear medicine and molecular imaging · 2026Article
- Article
- Mapping the future: bibliometric analysis of omics research trends in non-small cell lung cancer.Discover oncology · 2025Article
- CT-based radiomics-deep learning model predicts occult lymph node metastasis in early-stage lung adenocarcinoma patients: A multicenter study.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Deep-embedded clustering by relevant scales and genome-wide association study in autism.PloS one · 2025Article
- Comparison of enzymatic and bisulfite-based methods for sequencing-based cell-free DNA methylation profiling.Frontiers in epigenetics and epigenomics · 2025Article
- A liquid biopsy assay for the noninvasive detection of lymph node metastases in T1 lung adenocarcinoma.Thoracic cancer · 2024Article
- Identification of colon cancer subtypes based on multi-omics data-construction of methylation markers for immunotherapy.Frontiers in oncology · 2024Article
- Clinical application of ctDNA in early diagnosis, treatment and prognosis of patients with non-small cell lung cancer.Future oncology (London, England) · 2024Review
- Occult lymph node metastasis is not a favorable factor for resected NSCLC patients.BMC cancer · 2023Article
- Risk profiles and a concise prediction model for lymph node metastasis in patients with lung adenocarcinoma.Journal of cardiothoracic surgery · 2023Review
- Lung cancer with PET/CT-defined occult nodal metastasis yields favourable prognosis and benefits from adjuvant therapy: a multicentre study.European journal of nuclear medicine and molecular imaging · 2022Article
- Epigenetic mechanisms of lung carcinogenesis involve differentially methylated CpG sites beyond those associated with smoking.European journal of epidemiology · 2022Article
- Comparative Analysis of Mutation Status and Immune Landscape for Squamous Cell Carcinomas at Different Anatomical sites.Frontiers in immunology · 2022Article
- Genomics Analysis and Nomogram Risk Prediction of Occult Lymph Node Metastasis in Non-Predominant Micropapillary Component of Lung Adenocarcinoma Measuring ≤ 3 cm.Frontiers in oncology · 2022Article
- Seven DNA Methylation Biomarker Prediction Models for Monitoring the Malignant Progression From Advanced Adenoma to Colorectal Cancer.Frontiers in oncology · 2022Article
- The combination of a seven-autoantibody panel with computed tomography scanning can enhance the diagnostic efficiency of non-small cell lung cancer.Frontiers in oncology · 2022Article
- Review
- A Novel Immune-Related Prognostic Signature in Head and Neck Squamous Cell Carcinoma.Frontiers in genetics · 2021Article
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10 authors.
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Abstract
backgroundLymph node (LN) metastasis status is the most important prognostic factor and determines treatment strategy. Methylation alteration is an optimal candidate to trace the signal from early stage tumors due to its early existence, multiple loci and stability in blood. We built a diagnostic tool to screen and identify a set of plasma methylation markers in early stage occult LN metastasis.
methodsHigh-throughput targeted methylation sequencing was performed on tissue and matched plasma samples from a cohort of 119 non-small cell lung cancer (NSCLC) patients with a primary lesion of less than 3.0 cm in diameter. The methylation profiles were compared between patients with and without occult LN metastases. We carried out a set of machine-learning analyses on our discovery cohort to evaluate the utility of cell free DNA methylation profiles in early detection of LN metastasis. Two preliminary prognostic models predictive of LN metastasis were built by random forest with differentially methylated markers shared by plasma and tissue samples and markers present either in plasma or tissue samples respectively. The performance of these models was then evaluated using receiver operating characteristic (ROC) statistics derived from ten-fold cross validation repeated ten times.
resultsWithin this cohort, 27 cases (27/119, 22.7%) were found to have occult LN metastases found by pathological examination. Compared with those without metastases, 878 and 52 genes were differentially methylated in terms of tissue (
conclusionsWe identified a set of specific plasma methylation markers for early occult LN metastasis of NSCLC and established a preliminary non-invasive blood diagnostic tool.
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